Description
Our L-THP is an isoquinoline alkaloid, supplied as a powder. It’s tested to 99% purity or higher and sold strictly for lab research.
What is L-THP?
L-Tetrahydropalmatine is an alkaloid from Corydalis and Stephania plants, used in Chinese medicine for pain and sleep.
It was sold in China as a sedative under the name Rotundine.
How it works
L-THP blocks dopamine D1 and D2 receptors, which accounts for its calming and anti-addiction effects. It also acts on alpha-1 adrenergic and serotonin receptors.
Its dopamine blocking makes it different from most herbal sedatives.
Published L-THP research
Research covers its pain-relieving and sedative effects, and Chinese studies looked at it for reducing cravings in heroin users.
It has been linked to liver injury at high levels.
The primary literature is on PubMed. Here’s a search to start from.
Options and prices
This listing is 10g of powder for $25.68.
The powder is the bulk form, for labs that weigh their own amounts. Use a milligram scale for accuracy.
Using L-THP in the lab
Nootropic research usually uses memory and learning tests in rodents, such as maze tasks, object recognition or fear conditioning, along with markers like BDNF or receptor binding.
Behavioral tests are sensitive to handling and time of day, so labs keep both constant and score results blind. A vehicle group run on the same day is the most useful control.
Cognition studies mostly score behavior, such as maze learning or object recognition. Many also measure something in brain tissue afterwards, like BDNF or acetylcholine.
L-THP product details
- Compound: L-Tetrahydropalmatine
- Also known as: L-THP, rotundine
- CAS number: 10097-84-4
- Molecular formula: C21H25NO4
- Molar mass: 355.4 g/mol
- Structure: tetrahydroprotoberberine alkaloid
- Class: isoquinoline alkaloid
- Forms: powder
- Size: 10g
- Purity: 99% or higher, verified by first- and third-party testing
- Use: laboratory research only
Purity and batch testing
We test each batch for identity and purity before it ships, using HPLC and mass spectrometry, with independent third-party checks on top of our own.
The batch number on the label matches the certificate of analysis. If your lab keeps paperwork on file, ask us for it and we’ll email it over.
How to store L-THP
Keep the container sealed at room temperature, away from heat, moisture and sunlight. Write the date you opened or mixed it on the label, so anyone else in the lab knows how old it is.
Working with it safely
Treat it as a lab chemical. Gloves and safety glasses are the minimum, and a clean, uncluttered workspace cuts down on mix-ups.
Store prepared solutions apart from untouched stock, and record who mixed what and when.
Supplies to have on hand
- a milligram scale, since powder has to be weighed
- a suitable solvent if you’re making your own solution, such as DMSO or propylene glycol
Related products
- Evodiamine + Theacrine Tablets, combining Evodiamine and Theacrine
- Coluracetam: Coluracetam (MKC-231) is a racetam developed by Mitsubishi Tanabe Pharma in Japan.
- Uridine Liquid: Uridine monophosphate is a nucleotide used to build RNA.
- Orexin A: Orexin A, also called hypocretin-1, is a 33-amino-acid neuropeptide with two disulfide bridges.
- NSI-189 Phosphate: NSI-189 is a benzylpiperazine-aminopyridine compound from Neuralstem.
You can also browse our full nootropics pages.
Similar compounds compared
4F-Phenibut Free Base: 4F-Phenibut is 4-fluorophenibut, also called F-phenibut or CGP-11130. It’s phenibut with a fluorine atom on the phenyl ring, which makes it a stronger GABA-B agonist.
Phenylpiracetam Carphedon: Carphedon is the original name for phenylpiracetam (fonturacetam), a phenyl-substituted piracetam developed in Russia in 1983. It was used to help cosmonauts handle stress and fatigue.
Orexin A: Orexin A, also called hypocretin-1, is a 33-amino-acid neuropeptide with two disulfide bridges. It’s made by a small group of neurons in the lateral hypothalamus.
L-THP FAQ
Can it be used in people or animals?
No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.
How should I store it?
Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.
Is L-THP in stock?
Yes. It’s in stock and ships from our warehouse after your order clears.
Does it come with a certificate of analysis?
Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.
Order L-THP today
L-THP is in stock at $25.68. Add it to the cart and check out in a couple of minutes.
Need more for the same project? Have a look at our nootropics.
For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.
Reviews
There are no reviews yet.