Description
Pure Rawz Orexin A is a hypothalamic neuropeptide (hypocretin-1). Every batch is tested for 99% purity or better, and it’s sold for laboratory research only.
Orexin A explained
Orexin A, also called hypocretin-1, is a 33-amino-acid neuropeptide with two disulfide bridges. It’s made by a small group of neurons in the lateral hypothalamus.
It was discovered in 1998 by two groups at once, Sakurai’s team in Texas and de Lecea’s in California.
Mechanism of action
Orexin A binds both orexin receptors, OX1R and OX2R, with similar strength. These receptors keep wake-promoting brain systems active and also feed into appetite and reward circuits.
Its disulfide bonds make it more stable than orexin B.
What studies say about Orexin A
Loss of orexin neurons causes narcolepsy with cataplexy, which Nishino and colleagues showed in human patients in 2000. That finding made the orexin system a major target in sleep research.
Drugs that block orexin receptors, such as suvorexant, are now approved for insomnia.
To read the original papers, start with this PubMed search for Orexin A.
Orexin A sizes and forms
This listing is a single 5mg size, priced at $95.62.
Using Orexin A in the lab
Nootropic research usually uses memory and learning tests in rodents, such as maze tasks, object recognition or fear conditioning, along with markers like BDNF or receptor binding.
Behavioral tests are sensitive to handling and time of day, so labs keep both constant and score results blind. A vehicle group run on the same day is the most useful control.
Cognition studies mostly score behavior, such as maze learning or object recognition. Many also measure something in brain tissue afterwards, like BDNF or acetylcholine.
Orexin A at a glance
- Compound: Orexin A
- Also known as: hypocretin-1
- CAS number: 205640-90-0
- Molecular formula: C152H243N47O44S4
- Molar mass: 3,561.1 g/mol
- Structure: 33 amino acids, two disulfide bonds
- Class: hypothalamic neuropeptide (hypocretin-1)
- Size: 5mg
- Purity: 99% or higher, verified by first- and third-party testing
- Use: laboratory research only
How we test each batch
Every batch is tested before it goes on sale. Identity is checked by mass spectrometry, and purity by HPLC, with a target of 99% or higher.
Each container is labeled with the product, the amount and the batch number. Email us that number and we’ll send the certificate of analysis for your batch.
Keeping it fresh
Store capsules, tablets and powder in a cool, dry place out of direct light, with the lid closed tight. Note the batch number and the date you opened it in your lab records.
Working with it safely
Handle it the way you’d handle any research chemical: gloves, eye protection and a clean bench. Don’t eat or drink where you work with it.
Keep it out of reach of anyone who isn’t trained, and dispose of used syringes, vials and wipes according to your lab’s waste rules.
Often ordered alongside
- Alpha GPC: Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a choline source that breaks down into choline and glycerophosphate.
- Vincamine: Vincamine is an indole alkaloid from the leaves of lesser periwinkle (Vinca minor).
- Orexin B: Orexin B, or hypocretin-2, is a 28-amino-acid linear neuropeptide cut from the same precursor as orexin A.
- Aniracetam: Aniracetam is a fat-soluble racetam from Roche.
- Agmatine Sulfate: Agmatine is made in the body from arginine and works as a neuromodulator.
For the wider range, visit our nootropics sections.
Alternatives to consider
Magnesium L-Threonate Capsules: Magnesium L-threonate is magnesium bound to L-threonic acid, a vitamin C metabolite. It was developed at MIT to raise magnesium levels in the brain.
Coluracetam: Coluracetam (MKC-231) is a racetam developed by Mitsubishi Tanabe Pharma in Japan. It’s thought to boost high-affinity choline uptake, the step that limits how fast neurons make acetylcholine.
Orexin A questions
How should I store it?
Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.
Is Orexin A in stock?
Yes. It’s in stock and ships from our warehouse after your order clears.
Does it come with a certificate of analysis?
Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.
Can it be used in people or animals?
No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.
Buy Orexin A from Pure Rawz
Order Orexin A now for $95.62. It’s in stock, and checkout takes about two minutes.
Need more for the same project? Have a look at our nootropics and research peptides.
For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.
Reviews
There are no reviews yet.