HBT1

Description

HBT1 is an AMPA receptor potentiator, and Pure Rawz sells it as a powder. Each batch is checked for 99%+ purity. It’s intended for research use only.

About HBT1

HBT1 (CAS 489408-02-8) is a positive allosteric modulator of AMPA receptors from Takeda. It was chosen because it has very little direct agonist activity on its own.

That makes it lower risk for overstimulation than some older AMPA potentiators.

Mechanism of action

HBT1 binds a site on AMPA receptors and makes them respond more strongly to glutamate, without switching them on by itself.

That low intrinsic activity is meant to avoid the seizure risk seen with stronger AMPA activators.

HBT1 research

Kunugi and colleagues reported in Neuropsychopharmacology (2019) that HBT1 raised BDNF in neurons with little agonist effect.

Studies so far are preclinical.

For the studies themselves, try this PubMed search.

Choosing your option

This listing is 1g of powder for $92.36.

Powder suits labs that want to make their own solutions or capsules. Weigh it on a milligram scale.

Study design notes

Nootropic research usually uses memory and learning tests in rodents, such as maze tasks, object recognition or fear conditioning, along with markers like BDNF or receptor binding.

Behavioral tests are sensitive to handling and time of day, so labs keep both constant and score results blind. A vehicle group run on the same day is the most useful control.

Test a range of amounts if you can. Many cognition compounds have an inverted-U response, where too much works worse than a moderate amount.

HBT1 at a glance

• Compound: HBT1
• Class: AMPA receptor potentiator
• Forms: powder
• Size: 1g
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

Quality and testing

Every batch is tested before it goes on sale. Identity is checked by mass spectrometry, and purity by HPLC, with a target of 99% or higher.

Each container is labeled with the product, the amount and the batch number. Email us that number and we’ll send the certificate of analysis for your batch.

Keeping it fresh

Keep the container sealed at room temperature, away from heat, moisture and sunlight. Write the date you opened or mixed it on the label, so anyone else in the lab knows how old it is.

Working with it safely

Wear gloves and eye protection when you open or measure it, and work on a clean surface.

Label everything you prepare, keep it away from food areas, and follow your lab’s rules for disposing of sharps and chemical waste.

What you’ll need

• a milligram scale, since powder has to be weighed
• a suitable solvent if you’re making your own solution, such as DMSO or propylene glycol

Other compounds to look at

• Semax: Semax is a seven-amino-acid peptide (Met-Glu-His-Phe-Pro-Gly-Pro) based on a fragment of ACTH, with a Pro-Gly-Pro tail added for stability.
• Nefiracetam: Nefiracetam is a racetam from Daiichi Seiyaku.
• Phenibut HCl: Phenibut (beta-phenyl-GABA) is GABA with a phenyl ring added, which lets it cross into the brain.
• Coluracetam: Coluracetam (MKC-231) is a racetam developed by Mitsubishi Tanabe Pharma in Japan.
• L-Tetrahydropalmatine (L-THP): L-Tetrahydropalmatine is an alkaloid from Corydalis and Stephania plants, used in Chinese medicine for pain and sleep.

For the wider range, visit our nootropics sections.

Similar compounds compared

Picamilon Sodium (Nicotinoyl-GABA): Picamilon (N-nicotinoyl-GABA) joins GABA to niacin. It was made in the Soviet Union in 1969 and is registered in Russia.

Phenibut HCl: Phenibut (beta-phenyl-GABA) is GABA with a phenyl ring added, which lets it cross into the brain. It was developed in the Soviet Union in the 1960s.

MIF-1: MIF-1 is the tripeptide Pro-Leu-Gly-NH2, cut from the tail of oxytocin. It’s also known as melanostatin.

HBT1 questions

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

Is HBT1 in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

Order HBT1 today

Order HBT1 now for $92.36. It’s in stock, and checkout takes about two minutes.

Need more for the same project? Have a look at our nootropics.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.