NSI-189 Phosphate

Description

Our NSI-189 Phosphate is a neurogenic compound, supplied as capsules, a liquid and a powder. Each batch is checked for 99%+ purity. It’s intended for research use only.

About NSI-189 Phosphate

NSI-189 is a benzylpiperazine-aminopyridine compound from Neuralstem. It was picked in screens for drugs that grow new neurons in the hippocampus.

It’s sold here as the phosphate.

How it works

NSI-189 stimulates the growth of new neurons in the hippocampus and increases hippocampal volume in mice. Its exact molecular target hasn’t been published.

It’s one of the few compounds chosen for its effect on neurogenesis instead of a single receptor.

NSI-189 Phosphate research

Fava and colleagues reported a phase 1b trial in depression in Molecular Psychiatry (2016).

A larger phase 2 trial didn’t meet its main endpoint.

The primary literature is on PubMed. Here’s a search to start from.

Options and prices

It comes in 4 options. Pick one from the dropdown above the cart button:

• Capsules, 40mg per capsule/60ct/2.4g: $129.51
• Liquid, 30ml/33mg per ml/1000mg: $62.85
• Liquid, 30ml/67mg per ml/2000mg: $97.81
• Powder, 1g: $55.19

The capsules are pre-filled, so each one has the same amount. The size option lists it per capsule.

The liquid comes in a glass dropper bottle at a stated concentration per mL, so every draw is easy to calculate.

The powder is the bulk form, for labs that weigh their own amounts. Use a milligram scale for accuracy.

How labs use it

Nootropic research usually uses memory and learning tests in rodents, such as maze tasks, object recognition or fear conditioning, along with markers like BDNF or receptor binding.

Behavioral tests are sensitive to handling and time of day, so labs keep both constant and score results blind. A vehicle group run on the same day is the most useful control.

Test a range of amounts if you can. Many cognition compounds have an inverted-U response, where too much works worse than a moderate amount.

Measuring the liquid

At 33mg per mL, every 1mL holds 33mg and every 0.1mL holds 3.3mg. A graduated 1mL dropper or syringe makes those measures accurate.

NSI-189 Phosphate at a glance

• Compound: NSI-189
• Class: neurogenic compound
• Forms: capsules, liquid and powder
• Options: 4 sizes and forms
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

Purity and batch testing

We test each batch for identity and purity before it ships, using HPLC and mass spectrometry, with independent third-party checks on top of our own.

The batch number on the label matches the certificate of analysis. If your lab keeps paperwork on file, ask us for it and we’ll email it over.

How to store NSI-189 Phosphate

Store capsules, tablets and powder in a cool, dry place out of direct light, with the lid closed tight. Keep the bottle capped, upright and out of direct sunlight at room temperature unless the label says otherwise.

Label the container with the opening date. It saves guesswork later.

Handling notes

Wear gloves and eye protection when you open or measure it, and work on a clean surface.

Label everything you prepare, keep it away from food areas, and follow your lab’s rules for disposing of sharps and chemical waste.

What you’ll need

• a graduated 1mL dropper or syringe for accurate volumes
• a milligram scale, since powder has to be weighed
• a suitable solvent if you’re making your own solution, such as DMSO or propylene glycol

Other compounds to look at

• Neuro Bundle, combining Semax, Selank and Pinealon
• Cerebrolysin: Cerebrolysin is a mixture of low-weight peptides and amino acids from purified pig brain proteins.
• Tropisetron: Tropisetron is a 5-HT3 receptor antagonist approved in some countries to prevent chemotherapy nausea.
• Vinpocetine: Vinpocetine is a semi-synthetic derivative of vincamine, developed in Hungary by Gedeon Richter in the 1970s and sold there as Cavinton.
• TAK-653 Powder: TAK-653 is an AMPA receptor potentiator from Takeda with very low agonist activity.

See the rest of our nootropics for more options.

NSI-189 Phosphate questions

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

What forms does it come in?

Capsules, a liquid and a powder. Pick the one you want from the dropdown on this page.

Is NSI-189 Phosphate in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

Order NSI-189 Phosphate today

Ready to order? NSI-189 Phosphate starts at $55.19 and ships from stock. Add it to your cart and you’re done.

Need more for the same project? Have a look at our nootropics.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.