Orexin B

Description

Pure Rawz Orexin B is a hypothalamic neuropeptide (hypocretin-2). Every batch is tested for 99% purity or better, and it’s sold for laboratory research only.

What is Orexin B?

Orexin B, or hypocretin-2, is a 28-amino-acid linear neuropeptide cut from the same precursor as orexin A. It’s made by the same neurons in the lateral hypothalamus.

It has no disulfide bonds, so it breaks down faster than orexin A.

Mechanism of action

Orexin B binds OX2R much more strongly than OX1R. OX2R is the receptor most tied to keeping the brain awake.

That selectivity is why labs studying OX2R-driven wakefulness use orexin B as the reference agonist.

Published Orexin B research

Research on orexin B overlaps with orexin A and covers sleep, wakefulness, feeding and arousal. Because it prefers the OX2 receptor, it’s useful for separating the two receptor pathways.

Its role in narcolepsy comes from the same loss of orexin neurons.

The primary literature is on PubMed. Here’s a search to start from.

Orexin B sizes and forms

There are 2 ways to buy it, from $159.61 to $262.08:

• 1mg: $159.61
• 5mg: $262.08

How labs use it

Cognition studies often test a compound in a deficit model, for example after sleep loss, stress or a drug that impairs memory, because effects are easier to see there than in healthy animals.

Start with the smallest size to confirm solubility and handling, then scale up once the protocol is set.

Test a range of amounts if you can. Many cognition compounds have an inverted-U response, where too much works worse than a moderate amount.

Orexin B product details

• Compound: Orexin B
• Also known as: hypocretin-2
• CAS number: 205640-91-1
• Molecular formula: C126H215N45O34S
• Molar mass: 2,899.4 g/mol
• Structure: 28 amino acids, linear
• Class: hypothalamic neuropeptide (hypocretin-2)
• Options: 2 sizes and forms
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

How we test each batch

We test each batch for identity and purity before it ships, using HPLC and mass spectrometry, with independent third-party checks on top of our own.

The batch number on the label matches the certificate of analysis. If your lab keeps paperwork on file, ask us for it and we’ll email it over.

Keeping it fresh

Keep the container sealed at room temperature, away from heat, moisture and sunlight. Label the container with the opening date. It saves guesswork later.

Working with it safely

Handle it the way you’d handle any research chemical: gloves, eye protection and a clean bench. Don’t eat or drink where you work with it.

Keep it out of reach of anyone who isn’t trained, and dispose of used syringes, vials and wipes according to your lab’s waste rules.

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See the rest of our nootropics for more options.

Similar compounds compared

Adamax: Adamax is a modified form of Semax with an adamantane group attached. Adamantane is a rigid, cage-shaped carbon structure, and adding it is meant to make the peptide last longer and pass membranes more easily.

Pramiracetam: Pramiracetam is a fat-soluble racetam developed by Parke-Davis in the 1970s. It’s sold in Italy and some Eastern European countries.

Orexin B FAQ

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

What forms does it come in?

It comes in 2 sizes, listed in the dropdown on this page.

Is Orexin B in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Buy Orexin B online

Orexin B is in stock from $159.61. Choose your option, add it to the cart and check out in a couple of minutes.

Need more for the same project? Have a look at our nootropics and research peptides.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.