IDRA-21

Description

IDRA-21 is an AMPA receptor modulator, and Pure Rawz sells it as a powder. Each batch is checked for 99%+ purity. It’s intended for research use only.

What is IDRA-21?

IDRA-21 is a benzothiadiazine that reduces AMPA receptor desensitization. It’s related to the diuretic cyclothiazide.

It’s much longer-lasting than aniracetam in animal studies.

Mechanism of action

IDRA-21 slows AMPA receptor desensitization, so the receptor stays responsive to glutamate for longer. That strengthens the synaptic signals involved in memory formation.

Its long action is the main difference from other AMPA modulators.

IDRA-21 research

Thompson and colleagues reported in PNAS (1995) that IDRA-21 improved delayed matching tasks in rhesus monkeys.

Later work raised concerns about excitotoxicity at high concentrations.

To read the original papers, start with this PubMed search for IDRA-21.

Choosing your option

It comes in 3 options. Pick one from the dropdown above the cart button:

• Powder, 500mg: $17.47
• Powder, 1000mg: $25.12
• Powder, 5000mg: $89.62

The powder is the bulk form, for labs that weigh their own amounts. Use a milligram scale for accuracy.

Using IDRA-21 in the lab

Cognition studies often test a compound in a deficit model, for example after sleep loss, stress or a drug that impairs memory, because effects are easier to see there than in healthy animals.

Start with the smallest size to confirm solubility and handling, then scale up once the protocol is set.

Cognition studies mostly score behavior, such as maze learning or object recognition. Many also measure something in brain tissue afterwards, like BDNF or acetylcholine.

IDRA-21 specifications

• Compound: IDRA-21
• Class: AMPA receptor modulator
• Forms: powder
• Options: 3 sizes and forms
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

Purity and batch testing

Every batch is tested before it goes on sale. Identity is checked by mass spectrometry, and purity by HPLC, with a target of 99% or higher.

Each container is labeled with the product, the amount and the batch number. Email us that number and we’ll send the certificate of analysis for your batch.

Storage and shelf life

Keep the container sealed at room temperature, away from heat, moisture and sunlight. Label the container with the opening date. It saves guesswork later.

Handling notes

Treat it as a lab chemical. Gloves and safety glasses are the minimum, and a clean, uncluttered workspace cuts down on mix-ups.

Store prepared solutions apart from untouched stock, and record who mixed what and when.

What you’ll need

• a milligram scale, since powder has to be weighed
• a suitable solvent if you’re making your own solution, such as DMSO or propylene glycol

Often ordered alongside

• 5-Deazaflavin: 5-Deazaflavin (CAS 26908-38-3) is a flavin analog in which the nitrogen at position 5 is swapped for carbon.
• Sunifiram: Sunifiram (DM-235) is a piperazine derived from piracetam’s structure, developed at the University of Florence.
• 7,8-Dihydroxyflavone (7,8-DHF): 7,8-Dihydroxyflavone is a natural flavone that activates TrkB, the receptor for BDNF.
• Nooglutyl: Nooglutyl (ONK-10, CAS 112193-35-8) is a Russian nootropic made from glutamic acid and 5-hydroxynicotinic acid.
• Agomelatine: Agomelatine is a melatonin MT1/MT2 agonist and a 5-HT2C antagonist, developed by Servier.

See the rest of our nootropics for more options.

Alternatives to consider

BPAP: BPAP ((R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane) is a catecholaminergic and serotonergic activity enhancer developed by Joseph Knoll in Hungary. It’s related to selegiline but works at much lower concentrations.

4F-Phenibut Free Base: 4F-Phenibut is 4-fluorophenibut, also called F-phenibut or CGP-11130. It’s phenibut with a fluorine atom on the phenyl ring, which makes it a stronger GABA-B agonist.

IDRA-21 FAQ

Is IDRA-21 in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

What forms does it come in?

A powder. Pick the one you want from the dropdown on this page.

Buy IDRA-21 from Pure Rawz

Order IDRA-21 now from $17.47. It’s in stock, and checkout takes about two minutes.

Need more for the same project? Have a look at our nootropics.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.