7,8-Dihydroxyflavone (7,8-DHF)

Description

Pure Rawz Dihydroxyflavone is a flavone TrkB agonist, available as a powder. Every batch is tested for 99% purity or better, and it’s sold for laboratory research only.

Dihydroxyflavone explained

7,8-Dihydroxyflavone is a natural flavone that activates TrkB, the receptor for BDNF. The catechol group on the A ring is needed for that activity.

It’s one of the best-known small-molecule TrkB agonists.

How it acts in research models

7,8-DHF binds the TrkB receptor and causes it to dimerize and switch on, the same way BDNF does. That triggers the PI3K/Akt and MAPK pathways that support neuron survival and synapse growth.

Unlike BDNF, it’s a small molecule that crosses into the brain, which is why it’s used as a BDNF mimic.

Published Dihydroxyflavone research

Jang and colleagues reported in PNAS (2010) that 7,8-DHF activated TrkB in mouse brain and protected neurons.

Later rodent studies covered memory, mood and Alzheimer’s models.

To read the original papers, start with this PubMed search for 7,8-DHF.

Dihydroxyflavone sizes and forms

This listing is 1g of powder for $22.69.

The powder is the bulk form, for labs that weigh their own amounts. Use a milligram scale for accuracy.

Using Dihydroxyflavone in the lab

Cognition studies often test a compound in a deficit model, for example after sleep loss, stress or a drug that impairs memory, because effects are easier to see there than in healthy animals.

Start with the smallest size to confirm solubility and handling, then scale up once the protocol is set.

Cognition studies mostly score behavior, such as maze learning or object recognition. Many also measure something in brain tissue afterwards, like BDNF or acetylcholine.

Dihydroxyflavone product details

• Compound: 7,8-DHF
• Class: flavone TrkB agonist
• Forms: powder
• Size: 1g
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

Quality and testing

We test each batch for identity and purity before it ships, using HPLC and mass spectrometry, with independent third-party checks on top of our own.

The batch number on the label matches the certificate of analysis. If your lab keeps paperwork on file, ask us for it and we’ll email it over.

How to store Dihydroxyflavone

Store capsules, tablets and powder in a cool, dry place out of direct light, with the lid closed tight. Write the date you opened or mixed it on the label, so anyone else in the lab knows how old it is.

Handling notes

Handle it the way you’d handle any research chemical: gloves, eye protection and a clean bench. Don’t eat or drink where you work with it.

Keep it out of reach of anyone who isn’t trained, and dispose of used syringes, vials and wipes according to your lab’s waste rules.

Before you start

• a milligram scale, since powder has to be weighed
• a suitable solvent if you’re making your own solution, such as DMSO or propylene glycol

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For the wider range, visit our nootropics sections.

Alternatives to consider

Phenylpiracetam Hydrazide: Phenylpiracetam hydrazide, also sold as fonturacetam hydrazide, is phenylpiracetam with the amide group swapped for a hydrazide. It’s a racetam derivative from Russian research.

Sulbutiamine: Sulbutiamine is two modified thiamine (vitamin B1) molecules linked by a disulfide bond. It was developed in Japan in the 1960s to get more thiamine into the brain.

Common questions about Dihydroxyflavone

Is Dihydroxyflavone in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

Buy Dihydroxyflavone online

Ready to order? Dihydroxyflavone starts at $22.69 and ships from stock. Add it to your cart and you’re done.

Need more for the same project? Have a look at our nootropics.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.