Agomelatine

Description

Agomelatine is a melatonergic agonist, and Pure Rawz sells it as a powder. Every batch is tested for 99% purity or better, and it’s sold for laboratory research only.

About Agomelatine

Agomelatine is a melatonin MT1/MT2 agonist and a 5-HT2C antagonist, developed by Servier.

It’s approved in Europe and Australia for depression.

How it acts in research models

Agomelatine activates melatonin MT1 and MT2 receptors, which resets the body clock, and blocks 5-HT2C serotonin receptors, which raises dopamine and noradrenaline in the frontal cortex.

The two actions together are thought to explain its effects on sleep and mood.

Agomelatine research

Phase 3 trials in Europe reported antidepressant effects and improved sleep.

Liver function monitoring is part of its approved use.

Its melatonin activity is why it’s often studied for effects on sleep and circadian rhythm alongside mood.

For the studies themselves, try this PubMed search.

Options and prices

This listing is 1g of powder for $61.76.

Powder suits labs that want to make their own solutions or capsules. Weigh it on a milligram scale.

How labs use it

Nootropic research usually uses memory and learning tests in rodents, such as maze tasks, object recognition or fear conditioning, along with markers like BDNF or receptor binding.

Behavioral tests are sensitive to handling and time of day, so labs keep both constant and score results blind. A vehicle group run on the same day is the most useful control.

Cognition studies mostly score behavior, such as maze learning or object recognition. Many also measure something in brain tissue afterwards, like BDNF or acetylcholine.

Agomelatine specifications

• Compound: Agomelatine
• Also known as: Valdoxan
• Class: melatonergic agonist
• Forms: powder
• Size: 1g
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

Purity and batch testing

Every batch is tested before it goes on sale. Identity is checked by mass spectrometry, and purity by HPLC, with a target of 99% or higher.

Each container is labeled with the product, the amount and the batch number. Email us that number and we’ll send the certificate of analysis for your batch.

Keeping it fresh

Keep the container sealed at room temperature, away from heat, moisture and sunlight. Write the date you opened or mixed it on the label, so anyone else in the lab knows how old it is.

Handling notes

Handle it the way you’d handle any research chemical: gloves, eye protection and a clean bench. Don’t eat or drink where you work with it.

Keep it out of reach of anyone who isn’t trained, and dispose of used syringes, vials and wipes according to your lab’s waste rules.

Before you start

• a milligram scale, since powder has to be weighed
• a suitable solvent if you’re making your own solution, such as DMSO or propylene glycol

Often ordered alongside

• Ibudilast: Ibudilast is a phosphodiesterase inhibitor sold in Japan for decades as an asthma and post-stroke dizziness drug.
• Vincamine: Vincamine is an indole alkaloid from the leaves of lesser periwinkle (Vinca minor).
• Phenibut FAA: Phenibut (beta-phenyl-GABA) is GABA with a phenyl ring added, which lets it cross into the brain.
• Nooglutyl: Nooglutyl (ONK-10, CAS 112193-35-8) is a Russian nootropic made from glutamic acid and 5-hydroxynicotinic acid.
• Magnesium L-Threonate Capsules: Magnesium L-threonate is magnesium bound to L-threonic acid, a vitamin C metabolite.

You can also browse our full nootropics pages.

How it compares

P-21: P021 is a small peptidergic compound derived from ciliary neurotrophic factor (CNTF), with an adamantane group added for stability. It’s studied for neurogenesis.

Methylene Blue: Methylene blue is a phenothiazine dye first made in 1876. It accepts and donates electrons, and at low concentrations it can feed electrons into the mitochondrial chain.

Agomelatine FAQ

Is Agomelatine in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

Order Agomelatine today

Ready to order? Agomelatine starts at $61.76 and ships from stock. Add it to your cart and you’re done.

Need more for the same project? Have a look at our nootropics.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.