Fevipiprant

Description

Pure Rawz Fevipiprant is a DP2 receptor antagonist, available as a powder. Every batch is tested for 99% purity or better, and it’s sold for laboratory research only.

About Fevipiprant

Fevipiprant (QAW039) is an oral antagonist of the prostaglandin D2 receptor DP2, also called CRTH2. Novartis developed it to cut eosinophil-driven airway inflammation.

It’s a useful tool for studying the PGD2 pathway.

Mechanism of action

Fevipiprant blocks DP2 (CRTH2), the receptor that prostaglandin D2 uses to recruit eosinophils and Th2 cells. Blocking it cuts eosinophil-driven inflammation in the airways.

The same receptor appears in hair follicle research, which is why DP2 blockers are studied there too.

What studies say about Fevipiprant

Gonem and colleagues reported in 2016 that it lowered sputum eosinophils in people with persistent asthma.

The larger LUSTER phase 3 trials didn’t meet their goals, and Novartis stopped development in 2019.

The primary literature is on PubMed. Here’s a search to start from.

Fevipiprant sizes and forms

This listing is 5g of powder for $144.17.

The powder is the bulk form, for labs that weigh their own amounts. Use a milligram scale for accuracy.

Using Fevipiprant in the lab

Researchers use reference compounds to anchor a study: if the known drug gives the expected result, the model is behaving. Then the new compound can be compared against it.

Use the published pharmacology as your starting point and record the exact form, such as the salt or the solution strength.

Endpoints follow the drug’s known pharmacology: blood pressure and heart rate for cardiovascular compounds, receptor binding or enzyme activity for assay work, or the specific tissue response the drug is known for.

Fevipiprant product details

• Compound: Fevipiprant
• Also known as: QAW039
• Class: DP2 receptor antagonist
• Forms: powder
• Size: 5g
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

Purity and batch testing

We test each batch for identity and purity before it ships, using HPLC and mass spectrometry, with independent third-party checks on top of our own.

The batch number on the label matches the certificate of analysis. If your lab keeps paperwork on file, ask us for it and we’ll email it over.

Keeping it fresh

Keep the container sealed at room temperature, away from heat, moisture and sunlight. Note the batch number and the date you opened it in your lab records.

Handling notes

Wear gloves and eye protection when you open or measure it, and work on a clean surface.

Label everything you prepare, keep it away from food areas, and follow your lab’s rules for disposing of sharps and chemical waste.

Supplies to have on hand

• a milligram scale, since powder has to be weighed
• a suitable solvent if you’re making your own solution, such as DMSO or propylene glycol

Often ordered alongside

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• Compound 7P: Compound 7P (CAS 1890208-58-8) is a sulfonamide-acetamide small molecule, formula C22H23N3O5S.
• Levothyroxine (T4): Levothyroxine is synthetic T4, thyroxine, the main hormone the thyroid gland makes.
• Nebivolol: Nebivolol is a highly beta-1 selective beta blocker, sold as Bystolic for high blood pressure.
• Minoxidil 5%: Minoxidil is a potassium channel opener developed by Upjohn as a blood pressure drug in the 1970s.

See the rest of our research compounds for more options.

Similar compounds compared

Amino Tadalafil: Aminotadalafil is a structural analog of tadalafil, with formula C21H18N4O4 and CAS 385769-84-6. It’s related to the PDE5 inhibitor class.

Mirodenafil: Mirodenafil (SK3530) is a PDE5 inhibitor developed by SK Chemicals in South Korea, where it’s approved for erectile dysfunction.

Fevipiprant questions

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

Is Fevipiprant in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Buy Fevipiprant online

Fevipiprant is in stock at $144.17. Add it to the cart and check out in a couple of minutes.

Need more for the same project? Have a look at our research compounds.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.