Description
Our CMS-121 is a fisetin derivative, supplied as a powder. Each batch is checked for 99%+ purity. It’s intended for research use only.
About CMS-121
CMS-121 is a synthetic derivative of fisetin, a flavonoid from strawberries, developed at the Salk Institute by Pamela Maher and David Schubert. It was optimised to protect neurons from several types of age-related stress at once.
It acts partly by inhibiting the enzyme acetyl-CoA carboxylase 1.
How it works
CMS-121 blocks fatty acid synthase and reduces lipid peroxidation in neurons. It also protects cells from ferroptosis, a form of cell death driven by oxidized lipids.
In aging mouse models, those effects were linked to better memory and lower inflammation.
CMS-121 research
Ates and colleagues reported in 2020 that it reduced memory loss and brain inflammation in Alzheimer’s model mice.
Other mouse studies looked at metabolic aging. Data are preclinical.
To read the original papers, start with this PubMed search for CMS-121.
CMS-121 sizes and forms
This listing is 2g of powder for $48.99.
The powder is the bulk form, for labs that weigh their own amounts. Use a milligram scale for accuracy.
How labs use it
Cognition studies often test a compound in a deficit model, for example after sleep loss, stress or a drug that impairs memory, because effects are easier to see there than in healthy animals.
Start with the smallest size to confirm solubility and handling, then scale up once the protocol is set.
Cognition studies mostly score behavior, such as maze learning or object recognition. Many also measure something in brain tissue afterwards, like BDNF or acetylcholine.
CMS-121 specifications
- Compound: CMS-121
- Class: fisetin derivative
- Forms: powder
- Size: 2g
- Purity: 99% or higher, verified by first- and third-party testing
- Use: laboratory research only
Quality and testing
Every batch is tested before it goes on sale. Identity is checked by mass spectrometry, and purity by HPLC, with a target of 99% or higher.
Each container is labeled with the product, the amount and the batch number. Email us that number and we’ll send the certificate of analysis for your batch.
Keeping it fresh
Store capsules, tablets and powder in a cool, dry place out of direct light, with the lid closed tight. Note the batch number and the date you opened it in your lab records.
Safe handling
Handle it the way you’d handle any research chemical: gloves, eye protection and a clean bench. Don’t eat or drink where you work with it.
Keep it out of reach of anyone who isn’t trained, and dispose of used syringes, vials and wipes according to your lab’s waste rules.
Before you start
- a milligram scale, since powder has to be weighed
- a suitable solvent if you’re making your own solution, such as DMSO or propylene glycol
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How it compares
GTS-21 HCl: GTS-21 (DMXB-A) is a partial agonist at alpha7 nicotinic acetylcholine receptors. It’s a derivative of anabaseine, a toxin found in marine worms.
Adamantyl Carbonyl Proline: Adamantyl carbonyl proline (ACA) is 1-(adamantane-1-carbonyl)pyrrolidine-2-carboxylic acid, CAS 35084-48-1. It joins an adamantane group to the amino acid proline.
CMS-121 questions
Does it come with a certificate of analysis?
Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.
Can it be used in people or animals?
No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.
How should I store it?
Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.
Is CMS-121 in stock?
Yes. It’s in stock and ships from our warehouse after your order clears.
Buy CMS-121 online
CMS-121 is in stock at $48.99. Add it to the cart and check out in a couple of minutes.
Need more for the same project? Have a look at our nootropics.
For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.
Reviews
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