Setipiprant

Description

Pure Rawz Setipiprant is a DP2 (CRTH2) receptor antagonist, available as a powder. It’s tested to 99% purity or higher and sold strictly for lab research.

What is Setipiprant?

Setipiprant is an oral antagonist of the prostaglandin D2 receptor DP2, also called CRTH2. Actelion first developed it for allergy and asthma.

It’s now studied mainly for male pattern hair loss.

Mechanism of action

Setipiprant blocks DP2, so prostaglandin D2 can’t send its signal. In hair follicles that signal appears to stop growth, and in allergy it recruits inflammatory cells.

It doesn’t touch androgen pathways, which makes it a different approach from finasteride.

What studies say about Setipiprant

Garza and colleagues reported in Science Translational Medicine (2012) that prostaglandin D2 is high in balding scalp and blocks hair growth through DP2. A phase 2 trial of setipiprant in hair loss followed.

Earlier allergy trials showed it was well tolerated.

To read the original papers, start with this PubMed search for Setipiprant.

Setipiprant sizes and forms

This listing is 5g of powder for $55.73.

The powder is the bulk form, for labs that weigh their own amounts. Use a milligram scale for accuracy.

How labs use it

Researchers use reference compounds to anchor a study: if the known drug gives the expected result, the model is behaving. Then the new compound can be compared against it.

Use the published pharmacology as your starting point and record the exact form, such as the salt or the solution strength.

Endpoints follow the drug’s known pharmacology: blood pressure and heart rate for cardiovascular compounds, receptor binding or enzyme activity for assay work, or the specific tissue response the drug is known for.

Setipiprant product details

• Compound: Setipiprant
• CAS number: 866460-33-5
• Molecular formula: C24H19FN2O3
• Molar mass: 402.4 g/mol
• Structure: tetrahydropyridoindole
• Class: DP2 (CRTH2) receptor antagonist
• Forms: powder
• Size: 5g
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

How we test each batch

We test each batch for identity and purity before it ships, using HPLC and mass spectrometry, with independent third-party checks on top of our own.

The batch number on the label matches the certificate of analysis. If your lab keeps paperwork on file, ask us for it and we’ll email it over.

Keeping it fresh

Keep the container sealed at room temperature, away from heat, moisture and sunlight. Label the container with the opening date. It saves guesswork later.

Safe handling

Handle it the way you’d handle any research chemical: gloves, eye protection and a clean bench. Don’t eat or drink where you work with it.

Keep it out of reach of anyone who isn’t trained, and dispose of used syringes, vials and wipes according to your lab’s waste rules.

Supplies to have on hand

• a milligram scale, since powder has to be weighed
• a suitable solvent if you’re making your own solution, such as DMSO or propylene glycol

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See the rest of our research compounds for more options.

Alternatives to consider

PP-405: PP-405 is a small-molecule compound from Pelage Pharmaceuticals, a UCLA spin-out, developed for hair loss as a topical treatment.

Vardenafil Citrate: Vardenafil is a phosphodiesterase type 5 inhibitor developed by Bayer and approved in 2003 as Levitra for erectile dysfunction. It’s structurally close to sildenafil, with a different ring system that makes it more potent at PDE5.

Setipiprant questions

Is Setipiprant in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

Buy Setipiprant online

Setipiprant is in stock at $55.73. Add it to the cart and check out in a couple of minutes.

Need more for the same project? Have a look at our research compounds.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.