Sarcosine

Description

Our Sarcosine is a GlyT1 inhibitor, supplied as a powder. Every batch is tested for 99% purity or better, and it’s sold for laboratory research only.

What is Sarcosine?

Sarcosine (N-methylglycine) is a natural amino acid derivative. It blocks the glycine transporter GlyT1 and acts at the NMDA receptor glycine site.

It’s studied in schizophrenia.

How it acts in research models

Sarcosine blocks GlyT1, the transporter that clears glycine from synapses. More glycine stays at the NMDA receptor’s glycine site, strengthening NMDA signaling.

That’s why it’s studied in schizophrenia, where low NMDA activity is a leading theory.

Sarcosine research

Lane and colleagues reported in 2008 that sarcosine added to antipsychotics improved symptoms.

Larger trials have been mixed.

It’s also an intermediate in the breakdown of choline to glycine.

To read the original papers, start with this PubMed search for Sarcosine.

Sarcosine sizes and forms

This listing is 50g of powder for $13.10.

Powder suits labs that want to make their own solutions or capsules. Weigh it on a milligram scale.

How labs use it

Nootropic research usually uses memory and learning tests in rodents, such as maze tasks, object recognition or fear conditioning, along with markers like BDNF or receptor binding.

Behavioral tests are sensitive to handling and time of day, so labs keep both constant and score results blind. A vehicle group run on the same day is the most useful control.

Test a range of amounts if you can. Many cognition compounds have an inverted-U response, where too much works worse than a moderate amount.

Sarcosine at a glance

• Compound: Sarcosine
• Class: GlyT1 inhibitor
• Forms: powder
• Size: 50g
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

How we test each batch

Every batch is tested before it goes on sale. Identity is checked by mass spectrometry, and purity by HPLC, with a target of 99% or higher.

Each container is labeled with the product, the amount and the batch number. Email us that number and we’ll send the certificate of analysis for your batch.

Keeping it fresh

Keep the container sealed at room temperature, away from heat, moisture and sunlight. Note the batch number and the date you opened it in your lab records.

Working with it safely

Treat it as a lab chemical. Gloves and safety glasses are the minimum, and a clean, uncluttered workspace cuts down on mix-ups.

Store prepared solutions apart from untouched stock, and record who mixed what and when.

What you’ll need

• a milligram scale, since powder has to be weighed
• a suitable solvent if you’re making your own solution, such as DMSO or propylene glycol

Other compounds to look at

• Uridine Monophosphate Disodium: Uridine monophosphate is a nucleotide used to build RNA.
• ISRIB: ISRIB (integrated stress response inhibitor) is a small molecule found at UCSF in Peter Walter’s lab.
• Hydrafinil: 9-Fluorenol (hydrafinil) is fluorene with a hydroxyl at the 9 position.
• L-Tetrahydropalmatine (L-THP): L-Tetrahydropalmatine is an alkaloid from Corydalis and Stephania plants, used in Chinese medicine for pain and sleep.
• BPAP: BPAP ((R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane) is a catecholaminergic and serotonergic activity enhancer developed by Joseph Knoll in Hungary.

See the rest of our nootropics for more options.

Similar compounds compared

4F-Phenibut Free Base: 4F-Phenibut is 4-fluorophenibut, also called F-phenibut or CGP-11130. It’s phenibut with a fluorine atom on the phenyl ring, which makes it a stronger GABA-B agonist.

N-Acetyl Selank Amidate: N-Acetyl Selank Amidate is Selank with an acetyl group on one end and an amide on the other. Selank itself is a seven-amino-acid peptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) built on tuftsin, a fragment of an antibody protein, and was developed at the Institute of Molecular Genetics in Moscow.

Sarcosine FAQ

Is Sarcosine in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

Buy Sarcosine online

Sarcosine is in stock at $13.10. Add it to the cart and check out in a couple of minutes.

Need more for the same project? Have a look at our nootropics.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.