MGF (Mechano Growth Factor)

Description

MGF is an IGF-1 splice variant peptide, sold by Pure Rawz for laboratory research. Every batch is tested for 99% purity or better, and it’s sold for laboratory research only.

MGF explained

Mechano growth factor is a version of IGF-1 that muscle makes after mechanical load or damage. It comes from alternative splicing of the IGF-1 gene and is called IGF-1Ec in humans. The research peptide is a synthetic copy of its unique E-domain tail, 24 amino acids long.

Geoffrey Goldspink’s group at the Royal Free Hospital in London described it in the 1990s and gave it the name.

How it works

When muscle is stretched or damaged, the IGF-1 gene is spliced differently and makes MGF first, before the main IGF-1 form. The idea is that MGF’s E-domain wakes up satellite cells, the muscle stem cells that repair fibers.

The synthetic E-peptide has no IGF-1 receptor binding domain, so any effect it has is meant to come through a different, still unidentified route. Free MGF peptide also breaks down within minutes, which is why a pegylated version exists.

MGF research

Yang and Goldspink reported in FEBS Letters in 2002 that the MGF E-peptide made muscle satellite cells divide more, separately from the main IGF-1 receptor.

Later studies looked at it in heart and nerve injury models. Some groups couldn’t reproduce every result, so the field still argues about how much of it acts on its own. All of the work is in cells and animals.

The primary literature is on PubMed. Here’s a search to start from.

MGF sizes and forms

It comes in 3 options. Pick one from the dropdown above the cart button:

• 2mg: $33.31
• 5mg: $82.51
• 10mg: $136.06

Using MGF in the lab

GH-axis studies often look at IGF-1 as the steadier marker, since a single GH reading can miss a pulse. Cortisol and prolactin are worth measuring too, because some secretagogues raise them.

Run each peptide on its own before you test combinations, so you know what each one contributes.

Typical endpoints are serum GH at several time points, IGF-1, IGFBP-3, and body composition in longer studies. Some labs also track sleep, since GH release peaks in deep sleep.

MGF at a glance

• Compound: MGF
• Also known as: mechano growth factor, IGF-1Ec E-peptide
• Molecular formula: C121H200N42O39
• Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys
• Class: IGF-1 splice variant peptide
• Options: 3 sizes and forms
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

Quality and testing

Every batch is tested before it goes on sale. Identity is checked by mass spectrometry, and purity by HPLC, with a target of 99% or higher.

Each container is labeled with the product, the amount and the batch number. Email us that number and we’ll send the certificate of analysis for your batch.

How to store MGF

Store capsules, tablets and powder in a cool, dry place out of direct light, with the lid closed tight. Write the date you opened or mixed it on the label, so anyone else in the lab knows how old it is.

Safe handling

Wear gloves and eye protection when you open or measure it, and work on a clean surface.

Label everything you prepare, keep it away from food areas, and follow your lab’s rules for disposing of sharps and chemical waste.

Often ordered alongside

• MK-777 (Acetamoren): MK-777 (sold as acetamoren) is listed as an analog of ibutamoren, the oral growth hormone secretagogue MK-677.
• Sermorelin: Sermorelin is GHRH(1-29), the first 29 amino acids of growth hormone releasing hormone.
• ACE-031: ACE-031 (ramatercept) is a fusion protein of the activin receptor type IIB and an antibody Fc fragment.
• Ghrelin Acetate: Ghrelin is a 28-amino-acid hormone made mostly in the stomach.
• Tesamorelin: Tesamorelin is the full 44-amino-acid GHRH with a trans-3-hexenoyl group added.

For the wider range, visit our growth hormone peptides sections.

Common questions about MGF

What forms does it come in?

It comes in 3 sizes, listed in the dropdown on this page.

Is MGF in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

Order MGF today

Order MGF now from $33.31. It’s in stock, and checkout takes about two minutes.

Need more for the same project? Have a look at our growth hormone peptides and research peptides.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.