Description
Our KPV is an alpha-MSH derived tripeptide, supplied as freeze-dried vials and a nasal spray. Every batch is tested for 99% purity or better, and it’s sold for laboratory research only.
About KPV
KPV is the tripeptide lysine-proline-valine, the C-terminal end of alpha-melanocyte stimulating hormone. It keeps alpha-MSH’s anti-inflammatory activity without the pigment effects.
It’s small enough to be taken up by gut cells through the PepT1 transporter, which is why it’s studied in models of gut inflammation.
How it acts in research models
Alpha-MSH calms inflammation through melanocortin receptors. KPV is its last three amino acids and keeps much of that anti-inflammatory activity.
Inside cells it lowers NF-kappaB signaling, the switch for many inflammatory genes. Gut cells take it up through the PepT1 transporter, which is why colitis models are where most of the work is.
What studies say about KPV
Dalmasso and colleagues reported in Gastroenterology (2008) that KPV reduced inflammation in mouse colitis models and was taken up through PepT1.
Laroui and colleagues later packaged KPV in nanoparticles and saw similar effects in mice.
To read the original papers, start with this PubMed search for KPV.
Options and prices
There are 4 ways to buy it, from $34.99 to $249.99:
- Peptide, 5mg: $34.99
- Peptide, 10mg: $59.99
- Peptide, 50mg: $229.99
- Nasal Spray, 500mcg per spray/50mg: $249.99
These vials are lyophilized powder. Mix them with bacteriostatic water when you’re ready to work with them, and keep unmixed vials cold until then.
The nasal spray is pre-mixed in a metered pump bottle. The label gives the amount per spray and the total, which makes the math simple.
How labs use it
Repair peptide research mostly uses injury models: tendon or ligament damage, skin wounds, gut lining injury or muscle strain. Healing time, tissue strength and histology are the usual endpoints.
Because injury models vary a lot between animals, labs use larger groups and blinded scoring. A sham-injury group helps separate the peptide’s effect from normal healing.
Typical endpoints include wound closure rate, tensile strength of repaired tissue, collagen deposition and new blood vessel counts on histology. Gut models often score ulcer size and lining thickness.
Reconstitution math
For the 5mg vial, the concentration depends on the volume of water:
- 1mL of bacteriostatic water gives 5mg/mL
- 2mL of bacteriostatic water gives 2.5mg/mL
- 3mL of bacteriostatic water gives 1.67mg/mL
Add the water slowly along the inside of the vial and roll it gently until the powder dissolves. Shaking can damage peptide chains.
KPV specifications
- Compound: KPV
- Also known as: Lys-Pro-Val
- CAS number: 67727-97-3
- Molecular formula: C16H30N4O4
- Molar mass: 342.4 g/mol
- Sequence: Lys-Pro-Val
- Class: alpha-MSH derived tripeptide
- Forms: peptide vial and nasal spray
- Options: 4 sizes and forms
- Purity: 99% or higher, verified by first- and third-party testing
- Use: laboratory research only
Quality and testing
We test each batch for identity and purity before it ships, using HPLC and mass spectrometry, with independent third-party checks on top of our own.
The batch number on the label matches the certificate of analysis. If your lab keeps paperwork on file, ask us for it and we’ll email it over.
How to store KPV
Keep sealed vials in a freezer at -20°C or a fridge at 2 to 8°C, away from light. After mixing, store the vial in the fridge and use it within about four weeks. Keep nasal spray bottles in the fridge once opened, capped and upright.
Write the date you opened or mixed it on the label, so anyone else in the lab knows how old it is.
Handling notes
Handle it the way you’d handle any research chemical: gloves, eye protection and a clean bench. Don’t eat or drink where you work with it.
Keep it out of reach of anyone who isn’t trained, and dispose of used syringes, vials and wipes according to your lab’s waste rules.
Before you start
- Bacteriostatic Water for reconstitution, or Sterile Water if you’ll use the whole vial at once
- sterile insulin-type syringes or pipettes for measuring
- alcohol swabs for the vial stopper
Often ordered alongside
- BPC-157: BPC-157 is a 15-amino-acid peptide based on a fragment of body protection compound, a protein first found in gastric juice.
- TB-500 Fragment 17-23: TB-500 Frag 17-23 is a seven-amino-acid piece of thymosin beta-4, Leu-Lys-Lys-Thr-Glu-Thr-Gln, usually with an acetyl cap on the first residue.
- Thymosin Beta-4 (TB-500): Thymosin beta-4 is a 43-amino-acid protein found in nearly every cell, where it binds actin and helps control cell movement.
- PAL-GHK: Pal-GHK (palmitoyl tripeptide-1) is the GHK tripeptide with a palmitic acid chain.
- LL-37 (CAP-18): LL-37 is the only cathelicidin antimicrobial peptide humans make.
See the rest of our healing and recovery peptides and peptide nasal sprays for more options.
KPV questions
Is KPV in stock?
Yes. It’s in stock and ships from our warehouse after your order clears.
Does it come with a certificate of analysis?
Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.
Can it be used in people or animals?
No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.
What do I mix it with?
Most labs use sterile bacteriostatic water. Add it slowly down the side of the vial and swirl gently until the powder dissolves. Don’t shake it.
How should I store it?
Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.
What forms does it come in?
Freeze-dried vials and a nasal spray. Pick the one you want from the dropdown on this page.
Buy KPV online
Order KPV now from $34.99. It’s in stock, and checkout takes about two minutes.
Need more for the same project? Have a look at our healing and recovery peptides and research peptides.
For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.
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