Mass Construction (MK-677 + RAD-140 + LGD-4033)

Description

Mass Construction combines MK-677, RAD-140 and LGD-4033 in one product. Every batch is tested for 99% purity or better, and it’s sold for laboratory research only.

Inside Mass Construction

MK-677

MK-677 (ibutamoren) is an orally active, nonpeptide growth hormone secretagogue developed by Merck. It mimics ghrelin at the GHS-R1a receptor, raising growth hormone and IGF-1. It’s often sold next to SARMs, but it isn’t one.

MK-677 binds GHS-R1a, the same receptor as ghrelin and the GHRP peptides, in the pituitary and hypothalamus. That boosts the size of natural GH pulses and lifts IGF-1 from the liver.

RAD-140

RAD-140 (testolone, also called vosilasarm) is a nonsteroidal SARM developed by Radius Health. In preclinical work it showed strong activity in muscle with much less effect on the prostate and seminal vesicles than testosterone.

RAD-140 binds the androgen receptor and drives androgen-responsive gene activity in muscle and bone, with partial activity in the prostate. In monkeys it raised lean mass at exposures that left prostate size mostly unchanged.

LGD-4033

LGD-4033 (ligandrol, also coded VK5211) is a nonsteroidal SARM discovered by Ligand Pharmaceuticals and later licensed to Viking Therapeutics. It binds the androgen receptor with high affinity and, in animal models, acts strongly on muscle and bone while sparing the prostate.

Like other SARMs, LGD-4033 binds the androgen receptor and the receptor complex moves into the nucleus to switch on androgen-responsive genes. Its binding is unusually tight, with a reported Ki around 1 nanomolar.

The idea behind Mass Construction

Labs pair these compounds because each works through a different pathway, so combining them covers more of the system in one study. A fixed mix also means one product, one label and no drift between separate containers.

Research behind Mass Construction

Nass and colleagues ran a two-year trial in healthy older adults, published in the Annals of Internal Medicine in 2008. MK-677 raised GH and IGF-1 to levels seen in young adults and increased fat-free mass, with rises in fasting glucose noted.

The founding paper is Miller and colleagues, ACS Medicinal Chemistry Letters, 2011, which described RAD-140’s discovery and its tissue selectivity in rats and monkeys.

A phase 1 study by Basaria and colleagues, published in the Journals of Gerontology in 2013, gave LGD-4033 to 76 healthy young men for 21 days. Lean body mass rose with the dose, and the study also reported dose-related drops in HDL cholesterol and testosterone.

For the original studies, start with this PubMed search for MK-677, RAD-140 and LGD-4033.

Choosing your option

It comes in one option (LGD-4033 1g Liquid + Rad-140 Testolone 1g Liquid + MK-677 1g Liquid), priced at $256.07.

Study design notes

Labs comparing SARMs usually match exposure time and measure the same panel across compounds: muscle and prostate weight in rodents, plus hormone and lipid markers. That tissue-selectivity ratio is what SARM research is built around.

Liquids make small, even measurements easy, while capsules and tablets suit studies that need a fixed amount per unit.

Run a baseline panel before exposure starts. Without it, hormone changes are hard to interpret.

Mass Construction product details

• Contains: MK-677, RAD-140 and LGD-4033
• Size: LGD-4033 1g Liquid + Rad-140 Testolone 1g Liquid + MK-677 1g Liquid
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

How we test each batch

We test each batch for identity and purity before it ships, using HPLC and mass spectrometry, with independent third-party checks on top of our own.

The batch number on the label matches the certificate of analysis. If your lab keeps paperwork on file, ask us for it and we’ll email it over.

How to store Mass Construction

Store capsules, tablets and powder in a cool, dry place out of direct light, with the lid closed tight. Write the date you opened or mixed it on the label, so anyone else in the lab knows how old it is.

Safe handling

Wear gloves and eye protection when you open or measure it, and work on a clean surface.

Label everything you prepare, keep it away from food areas, and follow your lab’s rules for disposing of sharps and chemical waste.

Other compounds to look at

• Ligandrol + MK-677 Stack (LGD-4033 + Ibutamoren), combining LGD-4033 and MK-677
• YK-11 (Myostine): YK-11 is a steroidal compound built on a dihydrotestosterone backbone, first described by Japanese researchers in 2011.
• Mass Strong (4-Andro + MK-677 + LGD-4033), combining 4-Andro, MK-677 and LGD-4033
• ACP-105: ACP-105 is a nonsteroidal SARM developed by Acadia Pharmaceuticals around 2008.
• S4 Andarine + Stenabolic + Cardarine (SR-9009 + GW-501516), combining S4 Andarine, SR-9009 and GW501516

For the wider range, visit our SARMs sections.

Mass Construction FAQ

Is Mass Construction in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

What’s in Mass Construction?

MK-677, RAD-140 and LGD-4033. The section above covers each one.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

Order Mass Construction today

Ready to order? Mass Construction starts at $256.07 and ships from stock. Add it to your cart and you’re done.

Need more for the same project? Have a look at our SARMs.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.