Tesofensine

Description

Our Tesofensine is a triple reuptake inhibitor, supplied as tablets. Every batch is tested for 99% purity or better, and it’s sold for laboratory research only.

What is Tesofensine?

Tesofensine is a phenyltropane triple reuptake inhibitor of serotonin, noradrenaline and dopamine, developed by NeuroSearch in Denmark. It was first studied in Parkinson’s and Alzheimer’s disease.

Weight loss in those trials shifted its development toward obesity.

Mechanism of action

Tesofensine blocks the reuptake transporters for three brain chemicals: serotonin, noradrenaline and dopamine. With reuptake blocked, more of each stays active at the synapse.

Raising noradrenaline and dopamine signaling in appetite circuits is thought to explain the reduced food intake seen in trials. It has a long half-life of several days.

Tesofensine research

Astrup and colleagues reported in The Lancet (2008) a phase 2 trial with up to about 11% weight loss over 24 weeks.

Raised heart rate and blood pressure were noted at higher doses.

For the studies themselves, try this PubMed search.

Choosing your option

There are 3 ways to buy it, from $156.65 to $391.94:

• Tablets, 250mcg per tablet/30ct/7.5mg: $156.65
• Tablets, 250mcg per tablet/60ct/15mg: $276.02
• Tablets, 250mcg per tablet/90ct/22.5mg: $391.94

Each tablet holds the same measured amount, which the size option spells out.

How labs use it

Labs testing exercise-mimetic compounds often compare a sedentary treated group with an exercised control group. That shows how close the compound gets to the effects of training.

Keep diet, housing temperature and activity the same between groups, since all three change metabolism on their own.

Record the time of day you dose and test. Several of these compounds act on the body clock, and timing changes the result.

Tesofensine product details

• Compound: Tesofensine
• CAS number: 195875-84-4
• Molecular formula: C17H23Cl2NO
• Molar mass: 328.3 g/mol
• Structure: phenyltropane small molecule
• Class: triple reuptake inhibitor
• Forms: tablets
• Options: 3 sizes and forms
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

How we test each batch

Every batch is tested before it goes on sale. Identity is checked by mass spectrometry, and purity by HPLC, with a target of 99% or higher.

Each container is labeled with the product, the amount and the batch number. Email us that number and we’ll send the certificate of analysis for your batch.

Keeping it fresh

Keep the container sealed at room temperature, away from heat, moisture and sunlight. Note the batch number and the date you opened it in your lab records.

Handling notes

Wear gloves and eye protection when you open or measure it, and work on a clean surface.

Label everything you prepare, keep it away from food areas, and follow your lab’s rules for disposing of sharps and chemical waste.

Before you start

• nothing extra for capsules or tablets, as each unit is pre-measured
• a dry, sealed container if you split a bottle between projects

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See the rest of our metabolic research compounds for more options.

Alternatives to consider

Adipotide: Adipotide (prohibitin-TP01) is a peptidomimetic that targets prohibitin on blood vessels feeding fat tissue, then triggers cell death in those vessels.

Synephrine Solution: Synephrine, or p-synephrine, is the main protoalkaloid in bitter orange (Citrus aurantium). It’s sold here as a liquid solution.

Tesofensine questions

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

What forms does it come in?

Tablets. Pick the one you want from the dropdown on this page.

Is Tesofensine in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Buy Tesofensine from Pure Rawz

Ready to order? Tesofensine starts at $156.65 and ships from stock. Add it to your cart and you’re done.

Need more for the same project? Have a look at our metabolic research compounds.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.