Protirelin (TRH Thyrotropin)

Description

Pure Rawz Protirelin is a thyrotropin-releasing hormone (TRH). Each batch is checked for 99%+ purity. It’s intended for research use only.

About Protirelin

Protirelin is synthetic TRH, the three-amino-acid hormone pGlu-His-Pro-NH2 that the hypothalamus uses to tell the pituitary to release TSH.

It was the first hypothalamic hormone to be sequenced, work that earned Roger Guillemin and Andrew Schally part of the 1977 Nobel Prize.

How it works

TRH binds TRH receptors on pituitary thyrotroph cells and triggers TSH release, and with it the release of thyroid hormones downstream. It also raises prolactin.

In the brain, TRH receptors are spread well beyond the hypothalamus, which accounts for its stimulant and arousal effects in animal models.

What studies say about Protirelin

Protirelin was used for decades as a diagnostic test of the thyroid axis. It also has effects in the brain, and researchers have studied it for arousal, depression and neuroprotection.

Its half-life is only minutes, which is why longer-acting analogs such as taltirelin were developed.

The primary literature is on PubMed. Here’s a search to start from.

Choosing your option

There are 2 ways to buy it, from $101.33 to $212.78:

• 20mg: $101.33
• 50mg: $212.78

Study design notes

GH-axis studies often look at IGF-1 as the steadier marker, since a single GH reading can miss a pulse. Cortisol and prolactin are worth measuring too, because some secretagogues raise them.

Run each peptide on its own before you test combinations, so you know what each one contributes.

Freeze-dried peptides are easy to store, so ordering enough for a full study at once keeps every group on the same batch.

Protirelin specifications

• Compound: Protirelin
• Also known as: TRH, thyrotropin-releasing hormone
• CAS number: 24305-27-9
• Molecular formula: C16H22N6O4
• Molar mass: 362.4 g/mol
• Structure: pGlu-His-Pro-NH2
• Class: thyrotropin-releasing hormone (TRH)
• Options: 2 sizes and forms
• Purity: 99% or higher, verified by first- and third-party testing
• Use: laboratory research only

Purity and batch testing

Every batch is tested before it goes on sale. Identity is checked by mass spectrometry, and purity by HPLC, with a target of 99% or higher.

Each container is labeled with the product, the amount and the batch number. Email us that number and we’ll send the certificate of analysis for your batch.

Keeping it fresh

Store capsules, tablets and powder in a cool, dry place out of direct light, with the lid closed tight. Write the date you opened or mixed it on the label, so anyone else in the lab knows how old it is.

Handling notes

Handle it the way you’d handle any research chemical: gloves, eye protection and a clean bench. Don’t eat or drink where you work with it.

Keep it out of reach of anyone who isn’t trained, and dispose of used syringes, vials and wipes according to your lab’s waste rules.

Related products

• CJC-1295 With DAC: CJC-1295 with DAC is modified GRF(1-29), the first 29 amino acids of growth hormone releasing hormone with four substitutions, plus a lysine carrying a maleimide linker.
• Trevogrumab: Trevogrumab (REGN1033) is a monoclonal antibody from Regeneron that binds myostatin.
• IGF-1 DES: IGF-1 DES is insulin-like growth factor 1 missing its first three amino acids, Gly-Pro-Glu.
• Ibutamoren (MK-677): MK-677 (ibutamoren) is an orally active, nonpeptide growth hormone secretagogue developed by Merck.
• GHRP-2 (Pralmorelin): GHRP-2 (pralmorelin) is a six-amino-acid synthetic peptide that acts on the ghrelin receptor and makes the pituitary release growth hormone.

You can also browse our full growth hormone peptides pages.

Similar compounds compared

Hexarelin: Hexarelin (examorelin) is a six-amino-acid peptide closely related to GHRP-6, with a methyl group added to one tryptophan to make it more stable. It was developed in Italy by Mediolanum Farmaceutici.

Ibutamoren (MK-677): MK-677 (ibutamoren) is an orally active, nonpeptide growth hormone secretagogue developed by Merck. It mimics ghrelin at the GHS-R1a receptor, raising growth hormone and IGF-1. It’s often sold next to SARMs, but it isn’t one.

Common questions about Protirelin

Does it come with a certificate of analysis?

Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.

Can it be used in people or animals?

No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.

How should I store it?

Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.

What forms does it come in?

It comes in 2 sizes, listed in the dropdown on this page.

Is Protirelin in stock?

Yes. It’s in stock and ships from our warehouse after your order clears.

Buy Protirelin from Pure Rawz

Ready to order? Protirelin starts at $101.33 and ships from stock. Add it to your cart and you’re done.

Need more for the same project? Have a look at our growth hormone peptides and research peptides.

For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.