Description
Our PNC-27 is a p53-derived membrane-active peptide, supplied for lab research. It’s tested to 99% purity or higher and sold strictly for lab research.
PNC-27 explained
PNC-27 is a 32-residue peptide that joins a sequence from p53 (residues 12-26, the HDM-2 binding region) to a membrane-penetrating sequence. It’s studied for its effects on cancer cell membranes.
It’s only been studied in cells and animals.
Mechanism of action
PNC-27’s p53 sequence binds HDM-2, which some cancer cells carry on their outer membrane. Binding there lets the peptide form pores and break the membrane.
Normal cells have little surface HDM-2, which is the proposed reason they’re spared.
PNC-27 research
Sarafraz-Yazdi and colleagues reported in PNAS (2010) that PNC-27 bound HDM-2 on cancer cell membranes and formed pores that killed the cells, while untransformed cells were spared.
Follow-up work looked at leukemia and pancreatic cancer cell lines.
The primary literature is on PubMed. Here’s a search to start from.
PNC-27 sizes and forms
This listing is a single 5mg size, priced at $163.40.
Study design notes
Researchers who work with peptides tend to order a small vial first to check solubility and handling, then move to larger sizes once the protocol is settled.
Keep a log of the batch number, the mixing date and the volume of water used. If results drift between runs, those three details are usually where the answer is.
If you’re new to a peptide, read two or three of the original papers before you start. They’ll show which endpoints moved, which didn’t, and how other labs set up their controls.
PNC-27 product details
- Compound: PNC-27
- Class: p53-derived membrane-active peptide
- Size: 5mg
- Purity: 99% or higher, verified by first- and third-party testing
- Use: laboratory research only
Quality and testing
We test each batch for identity and purity before it ships, using HPLC and mass spectrometry, with independent third-party checks on top of our own.
The batch number on the label matches the certificate of analysis. If your lab keeps paperwork on file, ask us for it and we’ll email it over.
Storage and shelf life
Keep the container sealed at room temperature, away from heat, moisture and sunlight. Write the date you opened or mixed it on the label, so anyone else in the lab knows how old it is.
Safe handling
Handle it the way you’d handle any research chemical: gloves, eye protection and a clean bench. Don’t eat or drink where you work with it.
Keep it out of reach of anyone who isn’t trained, and dispose of used syringes, vials and wipes according to your lab’s waste rules.
Other compounds to look at
- Lipopeptide: Lipopeptide here means a palmitoyl peptide, a short peptide with a fatty acid chain attached so it can get into the outer layers of the skin.
- PT-141: PT-141 (bremelanotide) is a cyclic seven-amino-acid peptide derived from melanotan II.
- SNAP-8: SNAP-8 (acetyl octapeptide-3) is an eight-amino-acid peptide that extends argireline by two amino acids.
- Super Human Blend (SHB): Super Human Blend is a 10mL injectable research blend with 865mg of free-form amino acids per vial: L-carnitine 220mg, L-citrulline 120mg, L-arginine 110mg, L-ornithine 110mg, NAC 75mg, L-lysine 70mg, L-proline 60mg, L-taurine 60mg and L-glutamine 40mg.
- B7-33: B7-33 is a short synthetic peptide based on the B chain of human relaxin-2.
You can also browse our full research peptides pages.
How it compares
DSIP (Delta Sleep-Inducing Peptide): Delta sleep-inducing peptide (DSIP) is a nine-amino-acid peptide first isolated from rabbit blood in 1977 by Schoenenberger and Monnier. It was named for its effect on slow-wave sleep in rabbits.
PT-141: PT-141 (bremelanotide) is a cyclic seven-amino-acid peptide derived from melanotan II. It activates melanocortin receptors, mainly MC4R, in the brain.
Common questions about PNC-27
Can it be used in people or animals?
No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.
How should I store it?
Follow the storage section above. In short: cold and dark for freeze-dried vials, room temperature and dry for capsules, tablets, powders and liquids, unless the label says otherwise.
Is PNC-27 in stock?
Yes. It’s in stock and ships from our warehouse after your order clears.
Does it come with a certificate of analysis?
Yes. Every batch is tested, and we’ll email the certificate of analysis for your batch number on request.
Buy PNC-27 from Pure Rawz
Order PNC-27 now for $163.40. It’s in stock, and checkout takes about two minutes.
Need more for the same project? Have a look at our research peptides.
For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.
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