Description
Overview of Ibudilast
Ibudilast is a phosphodiesterase inhibitor with pronounced anti-inflammatory and neuroprotective properties in research preclinical models. Researchers use ibudilast in laboratory studies primarily because of its unique properties that target neuroinflammation and glial cell activity.
Chemical Properties
| Pubchem CID | 3671 |
| Molecular Weight | 230.31 g/mol |
| Synonyms | ibudilast
50847-11-5 Ketas KC-404 Ibudilastum |
| Molecular Formula | C14H18N2O |
| CAS | 50847-11-5 |
| Chemical Structure Depiction 2D |
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| Chemical Structure Depiction 3D |
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| Solubility | DMF: 20 mg/ml
DMSO: 16 mg/ml Ethanol: 25 mg/ml Ethanol: PBS (pH 7.2) (1:11): 0.08 mg/ml |
How Does Ibudilast Work?
Researchers have found that Ibudilast may work by inhibiting phosphodiesterases (mainly PDE-4 and PDE-10) in preclinical research models. Additionally, researchers believe Ibudilast may also modulate glial cell activity to increase intracellular cAMP.
This helps reduce the production of pro-inflammatory cytokines and suppresses the overactivation of microglia and astrocytes in research preclinical models.
Research Application of Ibudilast
Ibudilast is studied in controlled laboratory models for the following potential research applications.
- Researchers use Ibudilast to study microglia and astrocyte activation in preclinical research models.
- Investigating glia-driven nociceptive modulation in experimental models.
Why Buy Ibudilast Online from Purerawz?
You can buy Ibudilast from our online shop at reasonable prices. Each batch of this product undergoes rigorous testing for purity, identity, and contaminants, ensuring consistency and safety.
Disclaimer
This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By placing an order, you agree to our Terms and Conditions.
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use
Reference Links
- Rolan, P., Hutchinson, M., & Johnson, K. (2009). Ibudilast: a review of its pharmacology, efficacy, and safety in respiratory and neurological disease. Expert Opinion on Pharmacotherapy, 10(17), 2897–2904. https://doi.org/10.1517/14656560903426189
- Welcome To Zscaler Directory Authentication. (2026). Cancer.gov. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ibudilast
- Ramezani, A., Varshosaz, J., Darash, S., & Ebne-Ali-Heydari, Y. (2025). A comprehensive systematic review of Ibudilast as a neuroprotective therapy for progressive multiple sclerosis. Multiple Sclerosis and Related Disorders, 104, 106807. https://doi.org/10.1016/j.msard.2025.106807
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