Description

S4 Andarine + Stenabolic (SR-9009) + Cardarine (GW-501516)

This research combination contains three synthetic compounds frequently examined in laboratory studies related to cell signaling, metabolic pathways, and receptor activity. Each compound interacts with a molecular target. It may be investigated how multiple signaling pathways may function simultaneously in controlled experimental models.

Andarine (S4) is studied for its interaction with androgen receptors, while SR-9009 acts on REV-ERB nuclear receptors involved in circadian biology. Cardarine (GW-501516) is examined as a PPAR-δ agonist associated with lipid metabolism and cellular energy regulation.

These compounds are a good framework and relevant for examining potential interactions between androgen receptor signaling, circadian rhythm regulation, and metabolic gene expression.

Each capsule contains the following compounds:

Compound	Amount
S4 Andarine	30 mg
SR-9009 (Stenabolic)	10 mg
Cardarine (GW-501516)	10 mg

Chemical Properties

Compound	CAS Number	Molecular Formula	Molecular Weight	IUPAC Name
Andarine (S4)	401900-40-1	C19H18F3N3O6	441.4 g/mol	(2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
SR-9009 (Stenabolic)	1379686-30-2	C20H24ClN3O4S	437.9 g/mol	ethyl3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate
Cardarine (GW-501516)	317318-84-6	C21H18F3NO3S2	471.5 g/mol	2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid

Research Applications

The combination of Andarine (S4), SR-9009, and Cardarine (GW-501516) is examined in laboratory environments to explore how multiple receptor systems interact in biological models. Some general areas where this combination may be explored in experimental settings include:

Metabolic Regulation Research

PPARδ activation and REV-ERB signaling pathways are associated with cellular energy regulation, lipid metabolism, and glucose handling. Researchers may examine how these pathways influence metabolic activity in tissue models.

Skeletal Muscle and Tissue Signaling Studies

Selective androgen receptor modulators are often studied in models evaluating androgen receptor signaling and its role in muscle tissue maintenance, protein synthesis pathways, and cellular differentiation.

Circadian Rhythm and Biological Clock Research

REV-ERB receptors are components of the molecular clock that regulate circadian rhythms. SR-9009 is sometimes used in laboratory studies examining gene expression related to sleep–wake cycles, metabolic timing, and cellular rhythm regulation.

Mechanism of Action

The compounds in this formulation interact with distinct molecular targets, allowing researchers to observe multiple signaling pathways within the same experimental framework.

Andarine (S4), in laboratory models, may bind to androgen receptors located in the cytoplasm of cells. This interaction can form a receptor-ligand complex that influences gene transcription associated with androgen signaling pathways.

SR-9009 (Stenabolic) acts as a synthetic agonist of the REV-ERB nuclear receptors (REV-ERBα and REV-ERBβ). These receptors are transcriptional regulators involved in circadian rhythm control and metabolic gene expression. Activation of REV-ERB receptors may influence cellular pathways linked to energy expenditure and circadian regulation.

Cardarine (GW-501516) functions as a PPARδ agonist. Peroxisome proliferator-activated receptor delta (PPARδ) is a nuclear receptor involved in lipid metabolism, glucose regulation, and mitochondrial activity.

Why Researchers Choose PureRawz

PureRawz focuses on supplying high-integrity research materials for laboratories, institutions, and independent researchers seeking reliable compounds for experimental work.

Each batch is accompanied by third-party Certificates of Analysis (COA) verifying:

• Compound identity
• Purity levels
• Analytical validation

These reports provide transparency and support reproducibility across research projects. for more information.

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY and not for veterinary or human use.

Research Disclaimer

This information is provided strictly for educational and scientific reference purposes.

All compounds described are supplied by PureRawz exclusively for laboratory research use.

All research involving these materials should be conducted under the appropriate regulatory oversight, including Institutional Review Board (IRB) or Institutional Animal Care and Use Committee (IACUC) guidelines when applicable.

By completing a purchase, customers acknowledge that the materials will be used solely for lawful laboratory research purposes.

References

Thevis, M., Geyer, H., Kamber, M., & Schänzer, W. (2009). Detection of the arylpropionamide-derived selective androgen receptor modulator (SARM) S-4 (Andarine) in a black-market product. Drug Testing and Analysis, 1(8), 387 392.
https://pubmed.ncbi.nlm.nih.gov/20355219/

Turza, A., Bosca, M., Mureșan-Pop, M., Mare, L., Borodi, G., & Popescu, V. (2025). Novel solid forms of Cardarine/GW501516 and their characterization by X-ray diffraction, thermal, computational, FTIR, and UV analysis. Pharmaceutics, 17(2), 152.
https://pubmed.ncbi.nlm.nih.gov/40006519/

Leaney, J., et al. (2021). Development and validation of SARMs and metabolic modulators screening using UHPLC-MS/MS: Application to doping analysis. Forensic Science International.
https://www.sciencedirect.com/science/article/pii/S1570023221005298