Reduced Glutathione

Description

What is Reduced Glutathione?

Research indicates that Reduced glutathione (GSH) is a vital tripeptide antioxidant. It is studied for its role in cellular responses to oxidative imbalance. It has been observed in biochemical systems to interact with reactive species and conjugate certain compounds.

Researchers study reduced glutathione (GSH) in laboratory models to understand its role in redox balance in controlled research settings. 

Note: Reduced Glutathione is not approved by the U.S. Food and Drug Administration as a drug for therapeutic claims. Its use varies by jurisdiction, including research and dietary supplement contexts. It is not intended for human or animal use.

Glutathione exists in two forms:

• Reduced (GSH)
• Oxidized (GSSG)

The reduced form (GSH) is the biologically active state commonly studied in research systems. In contrast, the oxidized form (GSSG) is produced when GSH participates in redox reactions and is converted after interacting with reactive molecules. 

Chemical Properties

Pubchem CID	124886
Molecular Formula	C10H17N3O6S
CAS	70-18-8
IUPAC Name	(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
Solubility	H2O: 20 mg/ml
Storage	-20°C
Molecular Weight	307.33 g/mol
Primary Health Hazard
Synonyms	glutathione 70-18-8 L-Glutathione reduced L-Glutathione Glutathion…
Purity	≥95%
2D Structure Depiction
3D Structure Depiction
Crystal Structure Depiction

How Does Reduced Glutathione Work?

Reduced glutathione functions as a key redox-active molecule that helps maintain cellular chemical balance in research preclinical models. 

Experimental studies have shown that reduced glutathione donates electrons to reactive oxygen species (ROS). It can also donate electrons to other unstable compounds, contributing to their neutralization  and preventing damage.

In the process, GSH is oxidized to glutathione disulfide (GSSG), as observed in laboratory models. The cells then may regenerate GSH from GSSG using specific enzymes, allowing the system to continuously cycle between reduced and oxidized states. 

Researchers believe that this recycling makes glutathione a key component of the intracellular antioxidant network.  

Potential Research Applications of Reduced Glutathione

Reduced Glutathione is studied in controlled laboratory models for the following potential research applications.

• Studying oxidative stress mechanisms and how reactive species are neutralized
• Evaluating redox balance using the GSH to GSSG ratio as an indicator of system conditions
• Investigating detoxification pathways and interactions with harmful compounds
• Exploring responses to environmental or chemical stressors in experimental models
• Serving as a biochemical marker to monitor changes in system stability and oxidative conditions

Where to buy Reduced Glutathione online for research purposes?

If you are looking to buy reduced glutathione for research purposes, Purerawz is a reliable choice.

We provide reference materials with each product we sell. Each of our products comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By placing an order, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human usage.

Reference Links 

• Weschawalit, S., Thongthip, S., Phutrakool, P., & Asawanonda, P. (2017). Glutathione and its antiaging and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology, Volume 10, 147–153. https://doi.org/10.2147/ccid.s128339
• Chatterjee, A. (2013). Reduced glutathione: a radioprotector or a modulator of DNA-repair activity? Nutrients, 5(2), 525–542. https://doi.org/10.3390/nu5020525
• ‌Averill-Bates, D. A. (2023). The antioxidant glutathione. Vitamins and Hormones, 109–141. https://doi.org/10.1016/bs.vh.2022.09.002