Osthole 98%

Description

Overview of Osthole 98%

Osthole (7-methoxy-8-(3-methyl-2-butenyl)-2H-chromen-2-one) is a naturally occurring prenylated coumarin compound commonly isolated from the mature fruit of Cnidium monnieri and other plant species, including Angelica, Archangelica, and Citrus. It belongs to the broader family of benzopyran-derived coumarins, a class of phytochemicals widely investigated for their biochemical activity in experimental systems.

Due to its defined chemical structure and occurrence in several medicinal plants, Osthole is utilized as a standard compound for studies in pharmacology and natural product chemistry. Not FDA approved. It is solely designed for use in laboratory research, not for human or animal consumption.

Chemical and Molecular Properties 

Osthole
PubChem CID	10228
Molecular Formula	C15H16O3
Synonyms	Osthol Ostole Ostol
Molecular Weight	244.28 g/mol
IUPAC	7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one
Chemical Structure Depiction
Purity	≥98% (research grade)
CAS	484-12-8
Classification	Prenylated coumarin
Storage Temperature	2–8°C (refrigerated, protected from light)
Solubility	Soluble in sterile water; may dissolve in DMSO

Mechanism of Action

Experimental studies indicate that osthole interacts with several intracellular signaling pathways. These interactions are examined primarily in cell-based assays and preclinical research models.

Modulation of Cyclic Nucleotide Signaling

Osthole has been reported to influence cyclic nucleotide pathways, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). These second messengers regulate kinase activity and transcriptional responses associated with cellular signaling networks.

Regulation of Kinase Signaling Pathways

Osthole has been observed to influence kinase signaling cascades, including

• Mitogen-activated protein kinase (MAPK) pathways
• PI3K/Akt signaling networks

These pathways play key roles in regulating cellular stress responses, apoptosis-related proteins, and transcription factors studied in molecular biology research.

Interaction with Inflammatory Enzyme Systems

Cell culture experiments have shown that osthole may modulate the activity of enzymes associated with inflammatory signaling pathways, including:

• Cyclooxygenase (COX) enzymes
• 5-Lipoxygenase (5-LO)
• Inducible nitric oxide synthase (iNOS)

These enzymes are commonly examined in biochemical studies investigating inflammatory mediator production and immune signaling pathways.

Calcium Channel and Ion Channel Modulation

Some electrophysiological research suggests that osthole may influence voltage-dependent calcium channels and related ion transport mechanisms. These interactions are studied in neuronal cell models to examine regulation of cellular excitability and signal transduction.

Research Applications of Osthole 98%

Osthole is widely used as a research compound in natural product pharmacology and molecular biology. Documented experimental applications include:

• Cellular Signaling Studies
• Inflammation Pathway Research
• Neurobiology and Ion Channel Research
• Natural Product Pharmacology

Why Choose PureRawz for Osthole 98%?

Buy Osthole 98% for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

Osthole 98% is an investigational chemical currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.

Reference Links

Lin H., You Q., Wei X., et al. Osthole, a Coumarin from Cnidium monnieri: A Review on Its Pharmacology, Pharmacokinetics, Safety, and Innovative Drug Delivery Platforms. American Journal of Chinese Medicine. https://pubmed.ncbi.nlm.nih.gov/39327653/ 

Li Y., Zhang Y., Wang H., et al. The in vitro and in vivo anti-inflammatory effect of osthole via blocking activation of the NF-κB and MAPK/p38 pathways. Inflammation. https://pubmed.ncbi.nlm.nih.gov/30878874/ 

Wang X., Zhang X., Yang L., et al. Osthole attenuates inflammatory responses and regulates the expression of inflammatory mediators in HepG2 cells. Pharmaceutical Biology. https://pubmed.ncbi.nlm.nih.gov/25876063/

Zhang Z., Leung W., Cheung H., Chan C. Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as a Natural Therapeutic Agent. Phytotherapy Research. https://pubmed.ncbi.nlm.nih.gov/26165199/

Chen Y., Fan X., Zhao Y., et al. Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in cancer cells. Biochemical and Biophysical Research Communications. https://pubmed.ncbi.nlm.nih.gov/28902342/ 

Sun X., Wang H., Wang Y., et al. Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of TRPV3 Channel. Molecular Pharmacology. https://pubmed.ncbi.nlm.nih.gov/30108138/

PubChem Compound Summary for Osthole (CID 10228). National Center for Biotechnology Information, U.S. National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/10228