Description
Mazdutide Overview
Mazdutide, also known as IBI-362, is a synthetic dual-receptor agonist peptide studied in preclinical and laboratory research models. It is designed to activate two primary receptors:
- GLP-1 receptor (GLP-1R)
- Glucagon receptor (GCGR)
Mazdutide is an acylated peptide analogue with structural modifications intended to enhance stability and prolong its half-life in experimental settings. Researchers investigate Mazdutide to understand receptor activity and downstream cellular signaling in metabolic research models.
Chemical and Molecular Properties
| PubChem CID | 167312357 |
| Molecular Formula | C207H317N45O65 |
| Molecular Weight | 4476 g/mol |
| Synonyms | IBI362
2259884-03-0 GTPL13924 IBI-362 |
| IUPAC | 20-[[(1S)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-2-methylpropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]hexanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]amino]-20-oxoicosanoic acid |
| CAS | 2259884-03-0 |
| Labeling | Research Use Only (RUO), not for human or animal consumption |
| Chemical Structure Depiction | |
| Purity | >95% |
| Classification | Research Use Only (RUO) |
| Storage Temperature | Store at -20°C (-4°F) for long-term stability |
| Solubility | Water, DMSO (research-grade solvents) |
| Safety | Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible |
Mechanisms of Action
Mazdutide functions as a dual-receptor peptide agonist in controlled laboratory studies. Its primary actions are observed through:
GLP-1 Receptor (GLP-1R) Activation
- Studied for effects on glucose-dependent cellular signaling in experimental models
- Explored for modulation of nutrient absorption and energy-processing pathways in preclinical research
Glucagon Receptor (GCGR) Activation
- Investigated for its influence on cellular energy regulation and metabolic signaling
- Studied for coordinated receptor signaling networks in laboratory models
Potential Research Applications
Mazdutide is used in preclinical and laboratory research to study:
- Receptor activation profiles: GLP-1R and GCGR signaling in experimental models
- Intracellular signaling pathways: Mapping downstream pathways in controlled research systems
- Metabolic pathway studies: Examining cellular energy regulation, glucose-dependent pathways, and receptor-mediated signaling networks
- Preclinical model studies: Investigating potential interactions with cellular metabolic and endocrine pathways
Disclaimer
This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use
References:
- Nalisa, D. L., Cuboia, N., Dyab, E., Jackson, I. L., Felix, H. J., Shoki, P., Mubiana, M., Oyedeji-Amusa, M., Azevedo, L., & Jiang, H. (2024). Efficacy and safety of Mazdutide on weight loss among diabetic and non-diabetic patients: a systematic review and meta-analysis of randomized controlled trials. Frontiers in Endocrinology, 15, 1309118. https://doi.org/10.3389/fendo.2024.1309118
- Guo, L., Zhang, B., Xue, X., Zhang, X., Cai, H., Jiang, H., Zhang, L., Jin, P., Wang, X., Cheng, Z., Zhang, S., Geng, J., Guo, Y., Hu, H., Ma, Q., Li, L., Du, H., Han-Zhang, H., Xue, F., . . . Investigators, O. B. O. T. D. (2025). Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes. Nature. https://doi.org/10.1038/s41586-025-10031-z
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