DNSP-11

Description

Overview of DNSP-11 

DNSP-11 (Dopamine Neuron Stimulating Peptide-11) is an 11-amino-acid peptide derived from the propeptide sequence of Glial Cell Line-Derived Neurotrophic Factor (GDNF). This compound is intended strictly for in vitro and preclinical research.

Chemical and Molecular Properties 

DNSP-11
PubChem CID	25168985 for DNSP-11
Molecular Formula	C50H81N15O18·xC2HF3O2 (TFA salt)
Molecular Weight	1180.27 g/mol (C50H81N15O18)
Synonyms	Dopamine Neuron Stimulating Peptide-11, GDNF Propeptide Fragment-11
IUPAC Condensed	H-Arg-Leu-Ser-Gln-Ser-Ala-Asp-Gln-Tyr-Leu-OH
CAS	Not available
Labeling	Research Use Only (RUO)
Chemical Structure Depiction
Purity	≥98%
Classification	Research Use Only (RUO)
Storage Temperature	–20 °C recommended
Solubility	Typically soluble in water or PBS; may require gentle warming or sonication
Safety	Laboratory research use only; follow standard peptide handling procedures

DNSP-11 Mechanism

DNSP-11 is a peptide fragment derived from the glial cell line-derived neurotrophic factor (GDNF) proregion. Experimental studies investigate its interaction with signaling pathways associated with neurotrophic factor activity.

Interaction with GDNF-Related Signaling Pathways

DNSP-11 has been observed to influence signaling pathways associated with GDNF-mediated cellular communication. These pathways regulate intracellular signaling networks involved in neuronal cell signaling and survival mechanisms in preclinical research systems.

ERK Signaling Pathway Modulation

DNSP-11 activity in relation to the extracellular signal-regulated kinase (ERK) pathway, a signaling cascade involved in cellular communication and transcriptional regulation. Experimental models evaluate how DNSP-11 influences ERK pathway activation and associated intracellular signaling processes.

Mitochondrial and Cellular Stress Signaling

DNSP-11 in relation to mitochondrial activity and oxidative stress signaling pathways. These investigations examine how the peptide may influence intracellular responses to cellular stress in experimental neuronal cell models.

Note: All observations are limited to in vitro and preclinical research models. No therapeutic, clinical, or human/veterinary effects have been established.

Research Applications

DNSP-11 has been investigated primarily in cell-based assays and non-human preclinical models. Research focuses on:

• Peptide stability
• Receptor interactions
• Molecular signaling pathways

All experiments are research-only and do not indicate outcomes in humans or animals.

Why Choose PureRawz for DNSP-11?

Buy DNSP-11 for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

DNSP-11 is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

Bradley, L. H., Fuqua, J., Richardson, A., Turchan-Cholewo, J., Ai, Y., Kelps, K. A., Glass, J. D., He, X., Zhang, Z., Grondin, R., Littrell, O. M., Huettl, P., Pomerleau, F., Gash, D. M., & Gerhardt, G. A. (2010). Dopamine neuron stimulating actions of a GDNF propeptide. PLoS ONE, 5(3), e9752. https://doi.org/10.1371/journal.pone.0009752

Parmar, M. S., Allen, E., Narain, S., Khanna, D., & Cavanaugh, J. (2022). DNSP–11 reduces 6–OHDA–induced caspase 3/7 activation in an SH–SY5Y cell model: Potential role of ERK signaling pathway? The FASEB Journal, 36(S1). https://doi.org/10.1096/fasebj.2022.36.s1.l8063 

Stenslik, M. J. (n.d.). The intranasal delivery of DNSP-11 and its effects in animal models of Parkinson’s disease. University of Kentucky UKnowledge. https://uknowledge.uky.edu/neurobio_etds/14/