Description
CDP Choline Overview
Citicoline (CDP-Choline) is a nucleotide-derived compound studied in biochemical and neurological research. Structurally, it is composed of cytidine and choline linked through a diphosphate bridge. In biological systems, CDP-choline functions as an intermediate in the synthesis of phosphatidylcholine, an essential phospholipid found in cellular membranes.
Chemical and Molecular Properties
| PubChem CID | 13804 |
| Molecular Formula | C14H26N4O11P2 |
| Molecular Weight | 488.32 g/mol |
| Synonyms | citicoline
cytidine 5′-diphosphocholine 987-78-0 |
| IUPAC | [[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] 2-(trimethylazaniumyl)ethyl phosphate |
| CAS | 987-78-0 |
| Labeling | Research Use Only (RUO), not for human or animal consumption. |
| Chemical Structure Depiction | |
| Purity | 99% Purity |
| Classification | Research Use Only (RUO) |
| Storage Temperature | Store at -20°C (-4°F) |
| Solubility | Water, DMSO (research-grade solvents) |
| Safety | Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible |
Mechanism of Action
Laboratory investigations indicate that citicoline participates in several biochemical pathways associated with cellular membrane metabolism and neuronal signaling.
Research suggests that CDP-choline may influence the following cellular processes:
- Neurotransmitter pathway activity related to cholinergic signaling
- Phospholipid synthesis, particularly phosphatidylcholine production
- Mitochondrial energy metabolism in neural tissue models
- Inflammatory enzyme regulation, including phospholipase-related pathways
- Cellular antioxidant systems, including pathways associated with glutathione
In addition, CDP-choline is studied for its role in maintaining phosphatidylcholine and sphingomyelin, two phospholipids that contribute to neuronal membrane structure and myelin formation.
Potential Research Applications
In laboratory environments, citicoline is commonly studied in connection with:
- Phospholipid metabolism research
- Neurotransmitter signaling pathways
- Cell membrane synthesis and repair mechanisms
- Mitochondrial energy metabolism studies
- Neuroprotection and oxidative stress models
- Neuroscience and neurochemical signaling research
These properties make CDP-choline a compound of interest for investigations involving neuronal function, membrane biochemistry, and cellular signaling networks.
Disclaimer
This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use
References:
- Fioravanti, M., & Yanagi, M. (2005). Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database of Systematic Reviews, 2010(1), CD000269. https://doi.org/10.1002/14651858.cd000269.pub3
- Bruce, S. E. (2011). Improvements in quantitative EEG following consumption of a natural citicoline-enhanced beverage. International Journal of Food Sciences and Nutrition, 63(4), 421–425. https://doi.org/10.3109/09637486.2011.632623
- Ottobelli, L., Manni, G., Centofanti, M., Iester, M., Allevena, F., & Rossetti, L. (2013). Citicoline oral solution in glaucoma: Is there a role in slowing disease progression? Ophthalmologica, 229(4), 219–226. https://doi.org/10.1159/000350496
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