Description
LL-37 (CAP-18)
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LL-37 is a naturally occurring human antimicrobial peptide and the only member of the cathelicidin family expressed in humans.
It plays an important role in the body’s innate defense system and has attracted extensive research interest.
Product Information
LL-37 is generated from the precursor protein hCAP18 and is expressed by immune and epithelial cells.
It combines antimicrobial, immunomodulatory, wound-healing, and tissue-signaling properties.
How Does It Work?
LL-37 interacts with microbial membranes and multiple host-cell signaling pathways, influencing inflammatory responses, cell migration, and tissue repair.
Benefits
Supports Antimicrobial Defense
LL-37 demonstrates broad antimicrobial activity against bacteria and other pathogens, making it one of the most important endogenous host-defense peptides.
Supports Immune Regulation
LL-37 can modulate immune-cell signaling and inflammatory pathways rather than acting solely as a direct antimicrobial molecule.
Promotes Tissue Repair
Research links LL-37 to wound healing, epithelial activity, and tissue-repair pathways.
Supports Skin Defense
Because LL-37 is naturally expressed in epithelial tissues, it plays an important role in the skin’s first-line defense system.
Side Effects
LL-37 is biologically active and can produce inflammatory or irritating effects depending on concentration and tissue context. Human safety data for externally administered LL-37 remain limited.
Dosage
Community peptide sources have reported approximately 100–200 mcg once or twice daily, but this is not an established therapeutic dosage and should be treated only as an online-reported research range.
Research References
Bhattacharjya S, Zhang Z, Ramamoorthy A. LL-37: Structures, Antimicrobial Activity, and Influence on Amyloid-Related Diseases. Biomolecules. 2024.
PubMed — LL-37 Review
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The information provided is for educational and informational purposes only. Dosage figures may reflect published research protocols, historical human studies, or reported community practices and should not be interpreted as personalized medical instructions. Research findings—particularly those from animal, cellular, small human studies, or early-stage investigations—do not establish that a product is safe or effective for every individual or condition.
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