Pregnanolone

Product Overview

Pregnanolone is a member of this metabolite class and an endogenous neuroactive steroid derived from progesterone metabolism. It has been studied in laboratory research on inhibitory neurotransmission and neuroendocrine regulation.

Within steroidogenic pathways, progesterone is enzymatically converted through several intermediates, producing neurosteroids that influence neurotransmitter systems in the central nervous system. Pregnanolone is a member of this metabolite class and has been studied in laboratory research on inhibitory neurotransmission and neuroendocrine regulation.

Property	Data
Compound Name	Pregnanolone
PubChem CID	91451
CAS Number	128-20-1
Molecular Formula	C21H34O2
Molecular Weight	318.50 g/mol
Chemical Classification	Neurosteroid
IUPAC Name	1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
Synonyms	Pregnanolone ELTANOLONE
Strcuture
Source Database	PubChem (NCBI)

Working Mechanism

Pregnanolone has mostly been studied for its interaction with gamma-aminobutyric acid type A (GABA-A) receptors, which are a prominent inhibitory receptor system in the central nervous system. Neurosteroids can affect the activation of these receptors by binding to regulatory sites other than those used by classical neurotransmitters.

In many experimental settings, pregnanolone tends to behave as a positive allosteric modulator of GABA-A receptors. In this role, the chemical does not directly activate the receptor; rather, it modulates how sensitive it is to the endogenous neurotransmitter gamma-aminobutyric acid.

Research Applications

Pregnanolone appears in neurochemical studies investigating the role of neurosteroids in controlling synaptic inhibition. Neurosteroids are sometimes used as modulators in experimental models of GABAergic signaling to investigate how receptor activity varies in response to steroid-derived compounds.

Why Buy at PureRawz

PureRawz provides laboratory-grade research chemicals supported by independent Certificates of Analysis (COA) to verify purity and compound identity. Orders are packaged securely and processed through a streamlined checkout system with multiple payment options and shipment tracking for transparency. Researchers may also benefit from free shipping on orders of $100 or more, making it easier to obtain laboratory materials for ongoing experimental work

Note: Pregnanolone is distributed solely as a research chemical. It does not have approval from the U.S. Food and Drug Administration (FDA) for medical treatment or veterinary applications.

Research Disclaimer

The information presented is intended exclusively for educational and scientific reference. Products supplied by PureRawz are intended only for laboratory and analytical research.

ATTENTION: All products are FOR LABORATORY AND RESEARCH PURPOSES ONLY and NOT FOR HUMAN OR ANIMAL USE.

All experimental procedures should be conducted by qualified personnel in accordance with institutional regulatory oversight, such as IRB or IACUC protocols.

References

Belelli, D., & Lambert, J. J. (2005). Neurosteroids: Endogenous regulators of the GABA(A) receptor. Nature Reviews Neuroscience, 6(7), 565 575. https://pubmed.ncbi.nlm.nih.gov/15959466/

National Center for Biotechnology Information. (2024). Pregnanolone compound summary. PubChem Database. https://pubchem.ncbi.nlm.nih.gov/compound/91451

Reddy, D. S. (2010). Neurosteroids: Endogenous role in the human brain and therapeutic potentials. Progress in Brain Research, 186, 113 137. https://pubmed.ncbi.nlm.nih.gov/21094889/

National Library of Medicine. (2024). Neurosteroid pharmacology resources. https://www.nlm.nih.gov

ClinicalTrials.gov. (2024). Neurosteroid and GABA receptor research database. https://clinicaltrials.gov

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