Description
Buy AICAR Online
AICAR is a research compound widely studied for its ability to activate AMPK-related metabolic pathways. Human research has demonstrated measurable effects on skeletal-muscle glucose uptake, while broader performance and metabolic claims remain investigational.
Product Information
AICAR, also known as acadesine or 5-aminoimidazole-4-carboxamide ribonucleoside, is an AMP-mimetic compound used to study cellular energy metabolism. It has been investigated in glucose regulation, exercise physiology, inflammation, and AMPK signaling.
How Does It Work?
AICAR is converted intracellularly into ZMP, an AMP analogue that can influence AMP-sensitive metabolic signaling, particularly AMPK pathways. Human research has shown increased skeletal-muscle glucose uptake following AICAR exposure.
Benefits
AMPK & Energy-Metabolism Research
AICAR is an established pharmacological tool for investigating AMPK signaling and cellular responses to energy availability.
Skeletal-Muscle Glucose Uptake
A controlled human study involving 29 healthy men found that AICAR increased skeletal-muscle 2-deoxyglucose uptake and produced a smaller increase in whole-body glucose disposal.
Metabolic Research
AICAR has been extensively used to investigate glucose handling, fatty-acid metabolism, mitochondrial pathways, and cellular energy balance.
Inflammation Research
Experimental studies have examined AICAR-related effects on inflammatory signaling, including cytokine production in human adipose and skeletal-muscle cells.
Side Effects
Human safety information is limited relative to approved metabolic medicines. Potential concerns include changes in glucose metabolism, cardiovascular effects, altered energy metabolism, and route-specific adverse effects.
Dosage
AICAR has been administered experimentally in human research, but there is no established therapeutic dosage for general use. The 2007 human study used an intravenous research protocol rather than a consumer dosing regimen.
Where to Buy AICAR
Purerawz does not directly sell AICAR. Readers should verify compound identity, purity, analytical documentation, and supplier testing before evaluating third-party research sources.
References
Cuthbertson DJ et al. 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men. Diabetes. 2007;56(8):2078-2084.
The anti-diabetic AMPK activator AICAR reduces IL-6 and IL-8 in human adipose tissue and skeletal muscle cells. Molecular and Cellular Endocrinology. 2008.
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Purerawz does not sell, manufacture, stock, dispense, or directly supply any of the products discussed on this website. Purerawz is an independent information and affiliate platform. Where available, links may direct readers to independent third-party suppliers, and Purerawz may receive a commission from qualifying purchases at no additional cost to the reader.
The information on these pages is provided for educational and informational purposes only. Dosage figures may reflect published research protocols or reported community use and should not be interpreted as personalized medical instructions. Research findings, particularly animal and early-stage studies, do not necessarily translate into established human benefits or safety.
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